Table 1 A. pleuropneumoniae genes which are down-regulated during iron restriction
From: Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions
Gene ID | Gene | Description | Fold Change |
|---|---|---|---|
Hypothetical/Unclassified/Unknown | |||
ap0497 | engA | putative GTP binding protein | -2.27 |
ap0491 | glnE | Unknown | -1.98 |
ap1365 | srmB | uncharacterized conserved protein | -1.85 |
ap1538 | traC | conserved hypothetical protein | -1.72 |
ap0677 | nfnB | putative nitroreductase, FMN-dependent | -1.70 |
ap1779 | mscL | conserved hypothetical protein | -1.69 |
ap0802 | dxr | conserved hypothetical protein, distant homolog of PhoU | -1.58 |
ap0787 | cdsA | putative transcriptional regulator | -1.54 |
ap0685 | mlc | protein of unknown function | -1.53 |
ap1297+ | sspA | predicted iron-dependent peroxidase | -1.53 |
ap0973 | abgB | possible metal dependent peptidase, unclassified | -1.48 |
ap1405 | nth | possible sodium/sulphate transporter | -1.41 |
ap1725 | mviN | uncharacterized membrane protein, putative virulence factor | -1.38 |
ap0622 | aroC | flp operon protein C | -1.28 |
ap0989 | fstX | conserved hypothetical protein | -1.27 |
Biosynthesis of cofactors | |||
ap0684 | bioD1 | probable dethiobiotin synthetase | -3.49 |
ap1624 | menA | 1,4-dihydroxy-2-naphthoateoctaphenyltransferase | -1.57 |
ap1131 | hemC | porphobilinogen deaminase | -1.47 |
ap0447 | hemA | glutamyl-tRNA reductase | -1.40 |
ap1080 | hemN | oxygen-independent corproporphyrinogen III oxydase | -1.40 |
ap2005 | menB | naphthoate synthase | -1.39 |
ap1684 | ispH | hydroxymethylbutenyl pyrophosphate reductase | -1.37 |
ap2023 | - | 4-hydroxybenzoate synthetase | -1.31 |
Energy Metabolism | |||
ap0108+ | nrfA | nitrate reductase cytochrome c552 | -10.48 |
ap1694+ | frdA | fumarate reductase flavoprotein subunit | -9.20 |
ap1693+ | frdB | fumarate reductase iron-sulfur protein | -7.86 |
ap1536 | ccp | cytochrome C peroxidase | -6.61 |
ap0764+ | torY | nitrate/TMAO reducatse, tetraheme cytochrome C subunit | -6.27 |
ap0996+ | bisC | nitrate-inducible formate dehydrogenase-N α subunit | -5.68 |
ap0997+ | bisC | nitrate-inducible formate dehydrogenase-N α subunit | -5.40 |
ap0762+ | torZ | trimethylamine-N-oxide reductase 2 | -5.23 |
ap0998+ | hybA | formate dehydrogenase β subunit | -5.23 |
ap0498+ | ykgF | putative Fe-S electron transport protein | -4.78 |
ap1692+ | frdC | fumarate reductase 15 kD hydrophobic protein | -4.67 |
ap1937 | fumC | fumarate hydratase class II | -4.45 |
ap0499+ | ykgE | conserved putative dehydrogenase, Fe-S oxidoreductase | -4.38 |
ap1132+ | adh2 | alcool dehydrogenase 2 dehydrogenase | -3.36 |
ap1163+ | pflB | formate acetyltransferase | -3.01 |
ap1221 | aspA | aspartate ammonia-lyase | -2.78 |
ap1848+ | dmsA | dimethyl sulfoxyde reductase | -2.73 |
ap1222 | aspA | aspartate ammonia-lyase | -2.69 |
ap0110+ | nrfC | nitrate reductase, Fe-S protein | -2.63 |
ap0380 | glgB | 1,4-α-glucan branching enzyme | -2.55 |
ap0414 | glpK | putative glycerol kinase | -2.29 |
ap0109+ | nrfB | nitrate reductase, cytochrome C-type protein | -2.25 |
ap1255 | pfkA | Phosphofructokinase | -2.20 |
ap1486+ | hyaA | Ni-Fe hydrogenase I small subunit | -2.09 |
ap1525+ | ccmF | cytochrome C-type biogenesis protein | -1.98 |
ap1181+ | nfrE | cytochrome c-type biogenesis protein | -1.88 |
ap0418+ | glpA | anaerobic glycerol-3-phosphate dehydrogenase, subunit A | -1.76 |
ap0958+ | sdaA | L-serine dehydratase | -1.75 |
ap0420+ | glpC | anaerobic glycerol-3-phosphate dehydrogenase, subunit C | -1.72 |
ap1979 | torA | trimethylamine oxydoreductase precursor | -1.70 |
ap1528+ | ccmC | cytochrome C-type biogenesis protein | -1.69 |
ap1000+ | fdhE | formate dehydrogenase formation protein | -1.62 |
ap0328+ | cydB | cytochrome D ubiquinol oxidase subunit II | -1.61 |
ap1588+ | napF | ferredoxin-type protein | -1.55 |
ap1402 | pgk | phosphoglycerate kinase | -1.55 |
ap1585+ | torC | nitrate/TMAO reductase, tetraheme cytochrome C subunit | -1.53 |
ap0089 | dAK1 | dihydroxyacetone kinase | -1.51 |
ap0541 | maeA | malate oxydoreductase | -1.46 |
ap0326+ | cydA | cytochrome D ubiquinol oxidase subunit I | -1.45 |
ap0484 | gapA | glyceraldehydes-3-phosphate dehydrogenase | -1.35 |
ap1822 | atpH | ATP synthase δ chain | -1.28 |
ap1116 | galK | Galactokinase | -1.26 |
Transport and binding proteins: cations and iron | |||
ap0169+ | aopA | NADH-ubiquinone oxidoreductase, Na+-translocating A subunit (nqrA) | -2.38 |
ap0354 | nhaB | Na+/H+ antiporter protein | -2.14 |
ap0170+ | nqrB | NADH degydrogenase, Na+-translocating B subunit | -2.09 |
ap0172+ | nqrD | NADH-ubiquinone oxidoreductase, Na+-translocating D subunit | -2.05 |
ap0171+ | nqrC | NADH-ubiquinone oxidoreductase, Na+-translocating C subunit | -2.02 |
ap1972 | nadR | putative periplasmic binding protein, ABC metal ion uptake | -1.61 |
ap0173+ | nqrE | NADH-ubiquinone oxidoreductase, Na+-translocating E subunit | -1.52 |
Transport and binding proteins: others | |||
ap1470 | dcuB2 | anaerobic C4-dicarboxylate membrane transporter | -5.81 |
ap0416 | glpT | glycerol-3-phosphate transporter | -3.71 |
ap1835 | manX | PTS system enzyme IIAB, mannose specific | -2.28 |
ap1548 | mMT1 | PTS system mannose-specific EII AB component | -1.83 |
ap1473 | ptsB | PTS system, sucrose-specific IIBC component, | -1.67 |
ap1477 | ptsH | PTS system phosphocarrier protein HPr | -1.65 |
ap1620 | glpF | glycerol uptake facilitator | -1.56 |
ap1164 | focA | probable formate transporter | -1.54 |
ap0924 | cydC | ABC transporter involved in cytochrome bd biosynthesis | -1.51 |
ap1833 | hisS | PTS system component IID, mannose specific | -1.48 |
ap1580 | rbsB | galactose ABC transporter, periplasmic binding protein | -1.48 |
ap0886 | sapC | peptide transport system permease protein | -1.39 |
ap1698 | dcuB1 | anaerobic C4-dicarboxylate transporter | -1.38 |
ap2065 | mscS | small-conductance mechanosensitive channel | -1.37 |
ap1367 | PM0514 | permease of unknown function | -1.34 |
ap1478 | ptsI | phosphoenolpuruvate PTS system enzyme I | -1.32 |
ap1463 | proP | permease of the major facilitator superfamily | -1.32 |
ap1507 | artQ | arginine transport system permease protein | -1.22 |
Purines, pyrimidines, nucleosides and nucleotides | |||
ap2022 | udp | uridine phosphorylase | -2.21 |
ap1237 | purT | phorphoribosyglycinamide formyltransferase 2 | -1.67 |
ap0154 | pyrG | CTP synthase | -1.54 |
ap1922 | cdpC | 2',3'-cyclic-nucleotide 2'-phosphodiesterase | -1.46 |
ap0862 | pyrD | dihydroorotate dehydrogenase | -1.42 |
ap1204 | purA | adenylosuccinate synthetase | -1.37 |
ap0863 | prsA | ribose-phosphate pyrophosphokinase | -1.34 |
ap0729 | purE | phosphoribosylaminoimidazole carboxylase catalytic subunit | -1.33 |
Regulatory functions | |||
ap1392 | ansB | probable carbon starvation protein A, membrane bound | -2.59 |
ap1803 | glpR | transcriptional regulator of sugars metabolism | -1.51 |
ap1048 | baeS | sensory transduction histidine kinase | -1.36 |
Protein fate | |||
ap1485+ | hypF | Ni-Fe hydrogenase maturation protein | -2.39 |
ap2081 | lgt | prolipoprotein diacylglyceryl transferase | -1.58 |
ap0428 | pepB | peptidase B | -1.38 |
Protein synthesis | |||
ap0241 | thrS | threonyl-tRNA synthetase | -1.40 |
Cellular processes | |||
ap0725 | uspA | universal stress protein A | -1.59 |
ap0333 | tolB | colicin tolerance protein | -1.29 |
Cell envelope | |||
ap1215 | ompW | outer membrane protein W | -10.00 |
ap1156 | rplK | COG5039: exopolysaccharide biosynthesis protein | -1.32 |
ap0021 | HI1139 | UDP-N-acetylmuramate-alanine ligase (murC) | -1.23 |
ap1154 | ushA | glycosyltransferase involved in LPS biosynthesis | -1.19 |
Fatty acids and phospholipids metabolism | |||
ap2049 | accC | biotin carboxylase | -1.24 |
Amino acids biosynthesis | Â | Â | Â |
ap0351 | OB1054 | putative methionine synthase | -1.55 |
DNA metabolism | |||
ap1336 | - | putative hsdR, type 1 site-specific restriction-modification system, R subunit | -1.54 |
ap0703 | alxA-hsdM | type I restriction-modification system methylation subunit | -1.41 |
ap1247 | recQ | ATP-dependent DNA helicase | -1.21 |
Central intermediary metabolism | |||
ap1787 | ureC | urease α subunit | -1.45 |
ap1785 | ureE | metallochaperone for urease | -1.22 |