From: Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program
 | # transcripts with age effect | P-value |  | ||
---|---|---|---|---|---|
Biological Process | ↓Old | ↑Old | ↓Old | ↑Old | Ave. % CR Prevention |
lipid metabolism (4.5%) | 19 | 13 | <0.0005 | NS | 101 ± 9 |
protein metabolism (16.3%) | 55 | 61 | NS | NS | 88 ± 5 |
carbohydrate metabolism (2.7%) | 12 | 7 | <0.05 | NS | 91 ± 15 |
energy pathways (1.7%) | 10 | 2 | <<0.0005 | NS | 100 ± 20 |
stress response (5.2%) | 13 | 24 | NS | <0.05 | 90 ± 8 |
immune response (3.4%) | 4 | 20 | NS | <0.005 | 99 ± 10 |
apoptosis (3.7%) | 5 | 21 | NS | <<0.0005 | 62 ± 15 |
cell cycle (5.2%) | 9 | 28 | NS | <0.005 | 66 ± 8 |
cell adhesion (4.1%) | 18 | 11 | <0.05 | NS | 49 ± 14 |
cytoskeleton organization and biogenesis (3.9%) | 10 | 18 | NS | <0.005 | 102 ± 12 |