Table 2 List of Ingenuity networks generated by mapping the focus genes (PRGs) that were differentially expressed during neurodegeneration.

ALPL, CALM2, CLU, CNN3, CTSK, EEF1A1, EGR1, G3BP, GFRA2, GORASP2, GTF2I, HSPA9B(includesEG:3313), KLF16, KRT1, TC4S, MMP14, MYH11, MYL6, P4HA1, PDGFC, PGCP, PGRMC1, PRKCD, PRKCG, PSMA3, RAB1A, RAP1A, RET, SGPP1, SLC7A1, SMAD5, TBCD, TGFB1, TUBB2A, WBSCR1

52

35

Tissue Development, Cell Death, Endocrine System

ACTB, APOD, BTF3, CAPZB, CASK, CASKIN1, CCT6A, CREB1, CTNNB1, DBI, EPB41, ERBB2IP, ERP29, FGFR3, GJA1, GTF2F1, GTF2H1, HSP90AB1, ID4, LRRFIP2(includesEG:9209), NF2, NRXN1, PKD1, PRKCE, PTN, PTPRZ1, SDC3, SFRS1, SGK, SLC9A3R1, SST, TF, TNRC6A, TOB2, TRPC4

52

35

Behavior, Cellular Movement, Cell Cycle

APOE, B2M, CEBPD, CTSB, CTSS, HEXB, HLA-DMA, HLA-F, HMGCS2, HRSP12, IFNG, IL6, IL17A, IL1RL1, ITGB3, LAPTM4A, LY86, MCHR1, MLYCD, NR1D1, NR1H2, OSBPL1A, PLA2G5, POLR2D, POLR2F, POLR2G, POLR2I, POLR2J, POLR2K, POMP (includesEG:51371), RXRA, SLC37A4, TAP1, TLN1, ZMYND

19

19

Inflammatory Disease, Connective Tissue Disorders, Infectious Disease

ACTB, ALB, ATOX1, BID, CASP4, CEBPD, CLCN2, CLU, CST3, CTSB, CTSH, CTSS, DCTN2, DDIT3, DEFB103A, DEFB4(includesEG:1673), FKBP4, GFAP, GH1, GLUD1, GTPBP4, IRF1, MLLT4, NCKIPSD, NRXN2, SLPI, SNPH, TANK, TINF2, TP53, XRCC5, XRCC6, YWHAA, YWHAB, YWHAG

17

18

Cancer, Cell Death, Tumor Morphology

A2M, ALB, APBB3, APLP1(includesEG:333), APOA1, APOE, APP, ARPC3, CEBPD, CLU, CREB1, CST3, CTSD, DAB1, DOCK3, DPYSL2, FOXA1, FOXA2, FOXA3, HIP2, HMOX1, HSPG2 (includesEG:3339), LIF, MAPT, ONECUT1, PAX3, PTGS2, RAB11B, RASA2, RLBP1, SPON1, SYT2, THBS3, TM2D1, TTR

16

17

Cellular Assembly and Organization, Neurological Disease, Tissue Morphology