Figure 1
From: Bioinformatics prediction of overlapping frameshifted translation products in mammalian transcripts
Known examples of overlapping translated ORFs. A) The second exon of the INK4A and ARF genes is shared but translated in different reading frames. B) A transcript fusion can occur between the MASK and EIF4EBP3 genes, via an intermediate exon. In this case, the next exon is translated in a different frame from that in EIF4EBP3 transcripts. C) A splice variation in IGF-1 can cause a frameshift in the translation of C-terminal residues. D) Exon 1 of the G-protein subunit XL-alpha-s contains a second, frameshifted tRF which yields a distinct protein called Alex. Grey shading indicates overlapping frameshifted ORFs, exons and tORFs are drawn approximately to scale.