Figure 4

An Alu-derived TFBS upstream of the FOSL1 encoding gene. A schematic of the intron-exon structure of FOSL1, taken from the UCSC genome browser, is shown (blue) along with the positions of the repetitive DNA elements (black) at that locus. FOSL1 is encoded on the Crick strand of human chromosome 11. An Alu insertion (red) that donates a TCF-4 binding sites is found just upstream of the FOSL1 5' untranslated region in the proximal promoter region. Summary statistics and a sequence alignment between the FOSL1 proximal promoter sequence and the AluJb subfamily consensus sequence are shown with the TFBS location indicated (entire site boxed in red, contact residues highlighted in yellow).