Table 1 Summary of key features of the patatin-like lipases and CGI-58 from chicken (Gg) and man (Hs).
Name(s) | Chr. location Gg/Hs | Size cDNA (bp) Gg/Hs | Size protein (aa) Gg/Hs | Patatin domain (aa) Gg/Hs | Identity (%) Gg vs. Hs | Accession number mRNA Gg | Accession number mRNA Hs | Function(s) |
|---|---|---|---|---|---|---|---|---|
PNPLA1 | 26/ 6p21 | ?/ 1602 | ?/ 533 | 15–185/ 16–187 | ~46 | EU419876 | 89886440 | ? |
PNPLA2 ATGL iPLA2ζ desnutrin TTS-2 | 5/ 11p15.5 | 1452/ 1515 | 483/ 504 | 10–180/ 10–180 | 67 | EU419874 | 58759050 | TG hydrolysis [12], transacylase [10] |
PNPLA3 adiponutrin iPLA2ε | 1/ 22q13.31 | ?/ 1446 | ?/ 481 | ?/ 10–180 | ~49 | EU419875 | 17059635 | Lipase [11], transacylase [10] |
PNPLA4 iPLA2η GS2 | 1/ Xp22.3 | 762/ 762 | 253/ 253 | 6–177/ 6–177 | 76 | EU419877 | 458225 | Lipase [11], transacylase [10] |
PNPLA5 GS2-like | -/ 22q13 | -/ 1290 | -/ 429 | -/ 12–182 | - | - | 85397722 | Lipase [11] |
PNPLA6 NTE | ?/ 19p13.3-13.2 | ?/ 3984 | ?/ 1327 | ?/ 933–1100 | ~83 | EU419880 | 2982500 | Lysophospholipid hydrolysis [37], cell signaling [34] |
PNPLA7 NTE-related esterase NRE | 17/ 9q31.3 | 3975/ 3954 | 1324/ 1317 | 936–1103/ 928–1095 | 73 | EU419881 | 34531027 | Esterase [40], Lysophospho-lipase [39] |
PNPLA8 iPLA2γ | 1/ 7q31 | 2412/ 2349 | 803/ 782 | 465–661/ 445–640 | 59 | EU419878 | 7670057 | Potential lipase [19] |
PNPLA9 PLA2G6 iPLA2β | 1/ 22q13.1 | 2391/ 2421 | 796/ 806 | 472–657/ 481–666 | 62 | EU419879 | 3142699 | Lipase [29] |
CGI-58 ABHD5 | 2/ 3p21 | 1032/ 1050 | 343/ 349 | - | 79 | EU419873 | 33469972 | Activation of PNPLA2/ATGL [22] |