Skip to main content

Table 1 Differentially expressed genes.

From: Altered gene expression in highly purified enterocytes from patients with active coeliac disease

Functional Category

Gene Name

GenBank Accession Number

Chromosome Location

Fold-change

p-value

Protein Transport

peroxisome biogenesis factor 13

NM_002618

2p14-p16

2.276

0.00331

 

gap junction protein, alpha 4, 37 kDa (connexin 37)

NM_002060

1p35.1

1.952

0.00575

 

syntaxin 3A

NM_004177

11q12.1

1.81

0.00578

 

CD3G antigen, gamma polypeptide (TiT3 complex)

NM_000073

11q23

1.547

0.00676

 

retinol dehydrogenase 5 (11-cis and 9-cis)

NM_002905

12q13-q14

1.446

0.0158

 

exportin 1 (CRM1 homolog, yeast)

NM_003400

2p15

1.847

0.0225

 

A kinase (PRKA) anchor protein 1

NM_005751

7q21-q22

0.748

0.0248

 

retinol binding protein 1, cellular

NM_002899

3q21-q23

0.692

0.0305

Ion Transport

gamma-aminobutyric acid (GABA) A receptor, beta 3

NM_000814

15q11.2-q12

1.74

0.00286

 

cholinergic receptor, nicotinic, alpha polypeptide 5

NM_000745

15q24

0.557

0.00605

 

hemochromatosis

NM_000410

6p21.3

1.319

0.00924

 

potassium voltage-gated channel, Isk-related family, member 1

NM_000219

21q22.12

1.369

0.00959

 

calcium channel, voltage-dependent, L type, alpha 1C subunit

NM_000719

12p13.3

1.351

0.0112

 

sorcin

NM_003130

7q21.1

1.316

0.0248

 

ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A

NM_001691

3q13.2-q13.31

1.47

0.0364

 

glutamate receptor, ionotropic, N-methyl D-aspartate 1

NM_000832

9q34.3

0.706

0.0368

 

adenosine kinase

NM_001123

10q22.2

0.749

0.0406

Proliferation

bone marrow stromal cell antigen 2

NM_004335

19p13.2

1.29

0.00975

 

PRKC, apoptosis, WT1, regulator

NM_002583

12q21

0.73

0.0251

 

v-Ha-ras Harvey rat sarcoma viral oncogene homolog

NM_005343

11p15.5

0.631

0.0282

 

growth arrest-specific 6

NM_000820

13q34

1.576

0.0443

Differentiation

nuclear transcription factor Y, alpha

NM_002505

6p21.3

0.714

0.0196

 

homeo box A7

NM_006896

7p15-p14

1.701

0.0297

 

ash2 (absent, small, or homeotic)-like (Drosophila)

NM_004674

8p11.2

0.749

0.0368

 

wingless-type MMTV integration site family, member 7A

NM_004625

3p25

1.33

0.044

Anti-apoptosis/Survival

PTK2B protein tyrosine kinase 2 beta

NM_004103

8p21.1

0.719

0.00362

 

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

NM_001396

21q22.13

2.627

0.0304

 

tumor necrosis factor receptor superfamily, member 18

NM_004195

1p36.3

1.941

0.0334

 

Erythropoietin

NM_000799

7q22

2.738

0.0492

Transcription

SRY (sex determining region Y)-box 14

NM_006942

17p13

0.732

0.0142

 

hematopoietic cell-specific Lyn substrate 1

NM_005335

3q13

1.585

0.0164

 

histone deacetylase 2

NM_001527

6q21

1.574

0.0178

 

high-mobility group box 3

NM_002128

13q12

1.775

0.02

 

ELK4, ETS-domain protein (SRF accessory protein 1)

NM_001973

1q32

1.446

0.0216

 

homeo box A11

NM_005523

7p15-p14

1.325

0.0246

 

forkhead box G1B

NM_005249

14q13

1.558

0.0248

 

notch homolog 3 (Drosophila)

NM_000435

19p13.2-p13.1

1.271

0.0285

 

paired box gene 8

NM_003466

2q12-q14

1.419

0.0289

 

human T-cell leukemia virus enhancer factor

NM_002158

2p22-p16

1.267

0.0311

 

methyl CpG binding protein 2 (Rett syndrome)

NM_004992

Xq28

0.532

0.0326

 

T-box 6

NM_004608

16p11.2

0.73

0.037

 

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68 kDa

NM_003487

17q11.1-q11.2

0.656

0.0432

 

neuronal PAS domain protein 2

NM_002518

2q11.2

1.288

0.0497

Metabolism

fructose-1,6-bisphosphatase 1

NM_000507

9q22.3

1.535

0.000296

 

glucosidase, beta; acid (includes glucosylceramidase)

NM_000157

1q21

1.258

0.000369

 

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

NM_002130

5p14-p13

0.535

0.00679

 

lipoprotein, Lp(a)

NM_005577

6q26

1.653

0.0174

 

dihydropyrimidinase

NM_001385

8q22

0.638

0.0205

 

NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23 kDa (NADH-coenzyme Q reductase)

NM_002496

11q13

0.78

0.0242

 

histatin 1

NM_002159

4q13

0.75

0.0256

 

N-acetylgalactosaminidase, alpha-

NM_000262

22q13-qter; 22q11

0.783

0.0278

 

choline kinase

NM_001277

11q13.2

1.507

0.0303

 

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

NM_004567

3p22-p21

0.648

0.032

 

sterol regulatory element binding transcription factor 1

NM_004176

17p11.2

4.529

0.0354

Structural

cytoplasmic linker 2

NM_003388

7q11.23

1.309

0.00603

 

procollagen-lysine, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase) 2

NM_000935

3q23-q24

1.563

0.00657

 

spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

NM_003126

1q21

1.29

0.0108

 

cystatin A (stefin A)

NM_005213

3q21

1.48

0.0114

 

integrin beta 4 binding protein

NM_002212

20q12

2.356

0.0167

 

envoplakin

NM_001988

17q25

0.69

0.0201

 

tubulin-specific chaperone a

NM_004607

5q14.1

0.725

0.0239

 

microtubule-associated protein 1A

NM_002373

15q13-qter

0.652

0.0395

 

small proline-rich protein 3

NM_005416

1q21-q22

2.095

0.0398

Adhesion

vinculin

NM_003373

10q22.2

1.752

0.00217

 

matrix Gla protein

NM_000900

12p13.1-p12.3

0.659

0.00909

 

EGF-containing fibulin-like extracellular matrix protein 1

NM_004105

2p16

1.276

0.0273

 

oligodendrocyte myelin glycoprotein

NM_002544

17q11.2

2.008

0.0386

 

growth factor receptor-bound protein 7matrix Gla protein

NM_005310

17q12

1.564

0.0479

Protein Synthesis

ribosomal protein L19

NM_000981

17q11.2-q12

1.744

0.00118

 

eukaryotic translation elongation factor 1 beta 2

NM_001959

2q33-q34

1.413

0.0051

 

ribosomal protein S29

NM_001032

14q

1.311

0.00579

 

pyrroline-5-carboxylate reductase 1

NM_006907

17q25.3

1.31

0.0059

 

aminolevulinate, delta-, synthase 1

NM_000688

3p21.1

1.453

0.0105

 

eukaryotic translation initiation factor 4E binding protein 3

NM_003732

5q31.3

1.466

0.0143

 

tyrosinase (oculocutaneous albinism IA)

NM_000372

11q14-q21

1.272

0.0387

Immune Response & Inflammation

MAP/microtubule affinity-regulating kinase 2

NM_004954

11q12-q13

0.717

0.00307

 

microseminoprotein, beta-

NM_002443

10q11.2

1.592

0.0113

 

sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase)

NM_003032

3q27-q28

1.547

0.0207

 

pyruvate kinase, muscle

NM_002654

15q22

1.438

0.031

 

superkiller viralicidic activity 2-like (S. cerevisiae)

NM_006929

6p21

1.639

0.0401

Signal Transduction

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

NM_000906

1q21-q22

0.693

0.00936

 

membrane protein, palmitoylated 3 (MAGUK p55 subfamily) member 3)

NM_001932

17q21.31

1.259

0.0109

 

GPI anchored molecule like protein

NM_007264

12q13.3

1.791

0.0116

 

glutamate receptor, metabotropic 7

NM_000844

3p26.1-p25.1

0.768

0.026

 

G protein-coupled receptor 7

NM_005285

8p22-q21.13

2.293

0.0265

 

Ras-like without CAAX 1

NM_006912

1q22

1.306

0.0356

 

retinal G protein coupled receptor

NM_002921

10q23

0.744

0.0458

 

AND-1 protein

NM_007086

14q22.3

1.659

0.0465

Cell cycle & DNA repair

developmentally regulated GTP binding protein 1

NM_004147

22q12.2

1.56

0.00551

 

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)

NM_006223

Xq13

0.628

0.0086

 

flap structure-specific endonuclease 1

NM_004111

11q12

1.288

0.0167

 

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

NM_004656

3p21.31-p21.2

1.316

0.0185

 

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)

NM_001164

11p15

2.218

0.0234

 

ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)

NM_000462

15q11-q13

0.771

0.0286

 

nudix (nucleoside diphosphate linked moiety X)-type motif 2

NM_001161

9p13

2.209

0.037

Miscellaneous

chromosome 18 open reading frame 1

NM_004338

18p11.2

1.743

0.0298

 

prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia)

NM_000311

20p13

0.539

0.00875

 

oxidase (cytochrome c) assembly 1-like

NM_005015

14q11.2

0.625

0.0241

 

D-amino-acid oxidase

NM_001917

12q24

1.75

0.03

 

chromosome X open reading frame 2

NM_001586

Xq28

0.762

0.0308

 

transmembrane 7 superfamily member 1 (upregulated in kidney)

NM_003272

1q42-q43

0.761

0.0371

 

ribonuclease, RNase A family, 4

NM_002937

14q11.1

1.279

0.0467

  1. Genes are ranked within each category according to their significance.