From: Microarray analysis of toxicogenomic effects of Ortho-phenylphenol in Staphylococcus aureus
 |  | 20 min | 60 min |  |  |  | ||
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Affymetrix Probe ID | ORF no. | p-value | Fold change | p-value | Fold change | Description | Gene symbol | Functional class |
Group I: Upregulation (20 min) – Upregulation (60 min) 18 genes | ||||||||
sa_c6812s5946_a_at | SA0265 | 8.55E-06 | 2.1 | 8.55E-06 | 3.1 | peptidoglycan hydrolase (surface antigen) | lyt M | Cell envelope biogenesis, outer membrane |
sa_c7382s10191_a_at | SA0423* | 5.16E-07 | 8.1 | 5.16E-07 | 19.4 | hypothetical protein, similar to autolysin (N-acetylmuramoyl-L-alanine amidase) | Â | General function prediction only |
sa_c7698s6703_a_at | SA0519 | 0.00293 | 2.8 | 0.00293 | 2.5 | Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein | sdr C | Cell envelope biogenesis, outer membrane |
sa_c8045s7032_at | SA0620 | 1.27E-06 | 7.6 | 1.27E-06 | 5.6 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c592s9345_a_at | SA0905 | 4.83E-08 | 5.7 | 4.83E-08 | 7.0 | N-acetylglucosaminidase (major autolysin) | atl | Cell envelope biogenesis, outer membrane |
sa_c1007s793_a_at | SA1003 | 7.81E-06 | 3.7 | 7.81E-06 | 4.2 | fibrinogen-binding protein precursor | Â | hypothetical protein |
sa_c4394s3743_a_at | SA1898 | 7.99E-05 | 6.1 | 7.99E-05 | 5.8 | hypothetical protein, simialr to SceD precursor | Â | hypothetical protein |
sa_c4612s9984cs_s_at | SA1972 | 0.00267 | 2.2 | 0.00267 | 2.7 | multidrug resistance protein (efflux transporter) | Â | hypothetical protein |
sa_c5066s4362_a_at | SA2093* | 0.00025 | 6.8 | 0.00025 | 9.0 | hypothetical protein, similar to secretory antigen precursor SsaA | ssa A | General function prediction only |
sa_c5082s4380_a_at | SA2097* | 3.71E-05 | 6.9 | 3.71E-05 | 11.5 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c342s182_a_at | SA2142 | 9.36E-07 | 3.6 | 9.36E-07 | 3.6 | multidrug resistance protein B (drug efflux transporter) | Â | hypothetical protein |
sa_c5274s4572_a_at | SA2143 | 1.24E-07 | 3.9 | 1.24E-07 | 4.1 | multidrug resistance efflux pump | Â | hypothetical protein |
sa_c5652s4904_a_at | SA2206 | 0.00082 | 2.5 | 0.00082 | 2.8 | Immunoglobulin G binding protein A precursor | sbi | Cell envelope biogenesis, outer membrane |
sa_c6151s5333_a_at | SA2332 | 0.00019 | 7.8 | 0.00019 | 8.6 | hypothetical protein, similar to secretory antigen precursor SsaA | Â | General function prediction only |
sa_c6250s5428_a_at | SA2353* | 1.91E-05 | 10.2 | 1.91E-05 | 13.8 | secretory antigen precursor SsaA homolog | Â | General function prediction only |
sa_c9402s8223_a_at | SA2355* | 3.23E-06 | 8.5 | 3.23E-06 | 9.4 | transcriptional regulator, MARR family | Â | hypothetical protein |
sa_c6259s5439_a_at | SA2356 | 3.43E-06 | 6.5 | 3.43E-06 | 6.9 | immunodominant antigen A | isa A | Cell envelope biogenesis, outer membrane |
sa_c6506s5675_a_at | SA2423 | 0.00148 | 2.9 | 0.00148 | 3.5 | fibrinogen-binding protein A, clumping factor | clf B | Posttranslational modification, protein turnover, chaperones |
Group II: Upregulation (20 min) – No change (60 min) 28 genes | ||||||||
sa_c7511s6531_a_at | SA0459 | 0.000138 | 2.3 | Â | Â | ribosomal protein L25 (general stress protein Ctc) | rpl Y | Translation, ribosomal structure and biogenesis |
sa_c7621s6634_a_at | SA0497 | 7.95E-05 | 2.2 | Â | Â | 50S ribosomal protein L10; ribosomal protein L10 (BL5) | Â | Translation, ribosomal structure and biogenesis |
sa_c7625s6638_at | SA0498 | 5.07E-05 | 3.5 | Â | Â | 50S ribosomal protein L7:L12; ribosomal protein L7:L12 | Â | Translation, ribosomal structure and biogenesis |
sa_c1147s928_a_at | SA1041 | 0.00142 | 2.8 | Â | Â | uracil phosphoribosyltransferase; Pyrimidine operon regulatory protein pyrR | Â | Nucleotide transport and metabolism |
sa_c1151s932_a_at | SA1042 | 0.000143 | 6.7 | Â | Â | uracil permease (uracil transporter) | pyr P | Nucleotide transport and metabolism |
sa_c9991s8687_a_at | SA1043 | 7.66E-05 | 6.5 | Â | Â | aspartate carbamoyltransferase catalytic chain (Aspartate transcarbamylase) (ATCase) | pyr B | Nucleotide transport and metabolism |
sa_c1155s937_a_at | SA1044 | 0.000101 | 6.0 | Â | Â | dihydroorotase, dihydroorotase-like | pry C | Nucleotide transport and metabolism |
sa_c1159s942_a_at | SA1045 | 0.000161 | 5.1 | Â | Â | carbamoyl-phosphate synthase, arginine-specific, small chain | pyr AA | Amino acid transport and metabolism, Nucleotide transport and metabolism |
sa_c1165s946_a_at | SA1046 | 0.00018 | 3.3 | Â | Â | carbamoyl-phosphate synthase, arginine-specific, large chain | car B | Amino acid transport and metabolism, Nucleotide transport and metabolism |
sa_c1167s950_a_at | SA1047 | 0.000788 | 3.3 | Â | Â | orotidine 5-phosphate decarboxylase | pyr F | Nucleotide transport and metabolism |
sa_c9989s8682_a_at | SA1048 | 0.00107 | 3.0 | Â | Â | orotate phosphoribosyltransferase | pyr E | Nucleotide transport and metabolism |
sa_c1302s1077_a_at | SA1084 | 0.000221 | 2.7 | Â | Â | 50S ribosomal protein L19; ribosomal protein L19 | rpl S | Translation, ribosomal structure and biogenesis |
sa_c4792s4098_at | SA2022 | 0.000417 | 2.1 | Â | Â | 50S ribosomal protein L17; ribosomal protein L17 | rpl Q | Translation, ribosomal structure and biogenesis |
sa_c4824s4130_a_at | SA2029 | 2.76E-05 | 2.1 | Â | Â | 50S ribosomal protein L15; ribosomal protein L15 | rpl O | Translation, ribosomal structure and biogenesis |
sa_c4836s4142_at | SA2032 | 0.00024 | 2.1 | Â | Â | 50S ribosomal protein L18; ribosomal protein L18 | rpl R | Translation, ribosomal structure and biogenesis |
sa_c9951s8647_at | SA2033 | 0.000342 | 2.6 | Â | Â | 50S ribosomal protein L6; ribosomal protein L6 (BL8) | rpl F | Translation, ribosomal structure and biogenesis |
sa_c4848s4156_at | SA2035 | 0.0021 | 2.1 | Â | Â | 50S ribosomal protein L5; ribosomal protein L5 (BL6) | rps N | Translation, ribosomal structure and biogenesis |
sa_c4852s4158_at | SA2036 | 0.00267 | 2.1 | Â | Â | 50S ribosomal protein L24; ribosomal protein L24 (BL23) | rpl X | Translation, ribosomal structure and biogenesis |
sa_c10191s8871_a_at | SA2038 | 0.0026 | 2.8 | Â | Â | 30S ribosomal protein S17; ribosomal protein S17 (BS16) | rps Q | Translation, ribosomal structure and biogenesis |
sa_c4860s4166_at | SA2039 | 0.00204 | 2.5 | Â | Â | 50S ribosomal protein L29; ribosomal protein L29 | rpm C | Translation, ribosomal structure and biogenesis |
sa_c4864s4170_at | SA2040 | 0.000749 | 2.7 | Â | Â | 50S ribosomal protein L16; ribosomal protein L16 | rpl P | Translation, ribosomal structure and biogenesis |
sa_c4868s4175_a_at | SA2041 | 0.0024 | 2.8 | Â | Â | 30S ribosomal protein S3; ribosomal protein S3 (BS3) | rps C | Translation, ribosomal structure and biogenesis |
sa_c4876s4184_at | SA2043 | 0.00405 | 2.8 | Â | Â | 30S ribosomal protein S19; ribosomal protein S19 (BS19) | rps S | Translation, ribosomal structure and biogenesis |
sa_c9959s8654_a_at | SA2044 | 0.000888 | 2.5 | Â | Â | 50S ribosomal protein L2; ribosomal protein L2 (BL2) | rpl B | Translation, ribosomal structure and biogenesis |
sa_c10192s8875_a_at | SA2045 | 0.00434 | 2.7 | Â | Â | 50S ribosomal protein L23; ribosomal protein L23 | rpl W | Translation, ribosomal structure and biogenesis |
sa_c4880s4187_at | SA2046 | 0.00283 | 2.8 | Â | Â | 50S ribosomal protein L4; ribosomal protein L4 | rpl D | Translation, ribosomal structure and biogenesis |
sa_c4888s4195_a_at | SA2047 | 0.00069 | 2.3 | Â | Â | 50S ribosomal protein L3; ribosomal protein L3 (BL3) | rpl C | Translation, ribosomal structure and biogenesis |
sa_c9963s8658_a_at | SA2048 | 0.00245 | 2.4 | Â | Â | 30S ribosomal protein S10; ribosomal protein S10 (BS13) | rps J | Translation, ribosomal structure and biogenesis |
Group III: No change (20 min) – Upregulation (60 min) 8 genes | ||||||||
sa_c10571s9056_a_at | SA0845 | Â | Â | 0.000581 | 2.5 | putative oligopeptide ABC transporter integral membrane protein (fragment) | opp B | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c324s166_a_at | SA0846 | Â | Â | 0.00019 | 2.4 | probable peptide ABC transporter permease ABC transporter protein | opp C | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c328s170_a_at | SA0847 | Â | Â | 0.00293 | 2.2 | probable peptide ABC transporter ATP-binding ABC transporter protein | opp D | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c332s172_a_at | SA0848 | Â | Â | 9.13E-05 | 2.2 | probable peptide ABC transporter ATP-binding ABC transporter protein | opp F | Amino acid transport and metabolism |
sa_c5349s4625_a_at | SA0950 |  |  | 0.0022 | 2.2 | ABC transporter ATP-binding protein – spermidine:putrescine transport | pot A | Amino acid transport and metabolism |
sa_c795s596_a_at | SA0952 |  |  | 0.00536 | 2.2 | ABC transporter membrane-spanning permease – spermidine:putrescine transport | pot C | Amino acid transport and metabolism |
sa_c803s604_a_at | SA0953 | Â | Â | 0.00987 | 2.2 | spermidine:putrescine ABC transporter, spermidine: putrescine-binding periplasmic protein (potD) homolog | pot D | Amino acid transport and metabolism |
sa_c8848s7783_a_at | SA1601 | Â | Â | 0.000923 | 2.3 | CRCB, CrcB-like protein | Â | Cell division and chromosome partitioning |
Group IV: Downregulation (20 min) – Downregulation (60 min) 27 genes | ||||||||
sa_c5061s4360_a_at | SA0229 | 4.85E-07 | -5.8 | 4.85E-07 | -4.8 | dipeptide ABC transporter, periplasmic dipeptide-binding protein (dppA) | Â | Amino acid transport and metabolism |
sa_c736s544_a_at | SA0937 | 0.00365 | -2.9 | 0.00365 | -3.5 | cytochrome D ubiquinol oxidase subunit I | Â | Energy production and conversion |
sa_c740s548_a_at | SA0938 | 0.00375 | -2.9 | 0.00375 | -3.4 | cytochrome D ubiquinol oxidase subunit II homolog | Â | Energy production and conversion |
sa_c1659s1395_a_at | SA1164* | 0.000431 | -8.9 | 0.000431 | -3.4 | homoserine dehydrogenase (HDH) | dho M | Amino acid transport and metabolism |
sa_c1665s1401_a_at | SA1165 | 0.00011 | -8.3 | 0.00011 | -3.2 | threonine synthase (EC 4.2.3.1) homolog thrC | thr C | Amino acid transport and metabolism |
sa_c1669s1406_a_at | SA1166 | 5.06E-05 | -11.5 | 5.06E-05 | -3.8 | homoserine kinase (thrB) | thr B | Amino acid transport and metabolism |
sa_c1872s1598_a_at | SA1213 | 0.00127 | -2.8 | 0.00127 | -2.4 | probable peptide ABC transporter permease ABC transporter protein | opp- 2C | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c1876s1602_a_at | SA1214 | 8.58E-06 | -3.7 | 8.58E-06 | -3.0 | putative oligopeptide ABC transporter integral membrane protein (fragment) | opp-2B | Amino acid transport and metabolism, Inorganic ion transport and metabolism |
sa_c1912s1635_a_at | SA1225* | 8.90E-06 | -54.6 | 8.90E-06 | -7.7 | aspartokinase II in bifunctional enxyme: aspartokinase II; homoserine dehydrogenase II | lys C | Amino acid transport and metabolism |
sa_c1918s1640_a_at | SA1226* | 1.78E-05 | -21.5 | 1.78E-05 | -4.3 | aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASA DH) | asd | Amino acid transport and metabolism |
sa_c1922s1644_a_at | SA1227* | 2.75E-07 | -27.3 | 2.75E-07 | -5.2 | dihydrodipicolinate synthase (DHDPS) | dap A | Amino acid transport and metabolism, Cell envelope biogenesis, outer membrane |
sa_c1924s1648_a_at | SA1228* | 1.17E-07 | -31.4 | 1.17E-07 | -5.1 | dihydrodipicolinate reductase (DHPR) | dap B | Amino acid transport and metabolism |
sa_c1928s1652_a_at | SA1229* | 2.55E-07 | -23.5 | 2.55E-07 | -4.4 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase | dap D | Amino acid transport and metabolism |
sa_c1936s1659_a_at | SA1231 | 8.94E-08 | -18.5 | 8.94E-08 | -3.0 | Ala_racemase, Alanine racemase | Â | Cell envelope biogenesis, outer membrane |
sa_c3202s2750_a_at | SA1544 | 2.74E-05 | -15.8 | 2.74E-05 | -3.8 | serine-pyruvate aminotransferase; alanine-glyoxylate aminotransferase (Serine-pyruvate aminotransferase) | Â | Amino acid transport and metabolism |
sa_c3603s3083_a_at | SA1659 | 7.54E-06 | -2.4 | 7.54E-06 | -3.5 | parvulin-like PPIase precursor (Peptidyl-prolyl cis-trans isomerase plp) (Rotamase plp) | prs A | Posttranslational modification, protein turnover, chaperones |
sa_c10591s11046_s_at | SA1814 | 1.99E-05 | -3.3 | 1.99E-05 | -2.9 | succinyl-diaminopimelate desuccinylase (dapE) | Â | Amino acid transport and metabolism |
sa_c5023s4322_at | SA2082 | 6.38E-07 | -3.5 | 6.38E-07 | -5.5 | urease gamma chain (urea amidohydrolase) | ure A | Amino acid transport and metabolism |
sa_c5029s4326_a_at | SA2083 | 2.01E-06 | -4.3 | 2.01E-06 | -7.6 | URE2_staxy urease beta subunit | ure B | Amino acid transport and metabolism |
sa_c5031s4330_a_at | SA2084 | 1.84E-07 | -3.0 | 1.84E-07 | -4.4 | urease alpha chain (urea amidohydrolase) | ure C | Amino acid transport and metabolism |
sa_c5035s4334_at | SA2085 | 1.71E-05 | -2.9 | 1.71E-05 | -4.2 | urease accessory protein UreE | ure E | Posttranslational modification, protein turnover, chaperones |
sa_c5039s4340_a_at | SA2086 | 1.40E-05 | -2.3 | 1.40E-05 | -3.8 | urease accessory protein UreF | ure F | Posttranslational modification, protein turnover, chaperones |
sa_c9293s8136_a_at | SA2088 | 0.000118 | -2.2 | 0.000118 | -2.8 | urease accessory protein UreD | ure D | Posttranslational modification, protein turnover, chaperones |
sa_c5303s4583_a_at | SA2149 | 1.28E-07 | -35.8 | 1.28E-07 | -64.9 | probable peptide ABC transporter ATP-binding ABC transporter protein | Â | hypothetical protein |
sa_c5307s4587_at | SA2150 | 9.33E-07 | -36.5 | 9.33E-07 | -69.0 | ABC-type transporter, permease component | Â | hypothetical protein |
sa_c5777s5020_a_at | SA2235 | 2.82E-05 | -5.1 | 2.82E-05 | -3.5 | putative ABC transporter; osmoprotectant-binding protein, | opu CC | Cell envelope biogenesis, outer membrane |
sa_c6435s5604_a_at | SA2409 | 0.000134 | -4.6 | 0.000134 | -2.2 | anaerobic ribonucleoside-triphosphate reductase activating protein | Â | Posttranslational modification, protein turnover, chaperones |
Group V: Downregulation (20 min) – No change (60 min) 35 genes | ||||||||
sa_c37s34_a_at | SA0010 | 2.44E-06 | -4.7 | Â | Â | branched-chain amino acid permease | Â | Amino acid transport and metabolism |
sa_c4055s3432_a_at | SA0201 | 0.00111 | -2.3 | Â | Â | RGD-containing lipoprotein | rlp | Amino acid transport and metabolism |
sa_c7055s6165_a_at | SA0331 | 0.000236 | -3.0 | Â | Â | probable lipoprotein | Â | Inorganic ion transport and metabolism |
sa_c7100s6210_a_at | SA0344 | 2.80E-06 | -15.2 |  |  | methyltetrahydropteroyltriglutamate – homocysteine methyltransferase (vitamin-B12-independent methionine synthase isozyme) | met E | Amino acid transport and metabolism |
sa_c5418s4689_a_at | SA0420 | 7.55E-05 | -2.8 | Â | Â | probable amino acid ABC transporter, ATP-binding protein (abc) | Â | Inorganic ion transport and metabolism |
sa_c7374s6406_a_at | SA0421 | 6.63E-07 | -3.3 | Â | Â | putative amino acid ABC transporter, permease protein, glutamine transport system | Â | Inorganic ion transport and metabolism |
sa_c5431s4700_a_at | SA0769 | 2.32E-06 | -5.4 | Â | Â | probable amino acid ABC transporter, ATP-binding protein | Â | Inorganic ion transport and metabolism |
sa_c8512s7471_a_at | SA0770 | 1.42E-05 | -6.3 | Â | Â | permease protein of ABC transporter system | Â | Inorganic ion transport and metabolism |
sa_c8518s7475_a_at | SA0771 | 5.12E-06 | -7.5 | Â | Â | probable D-methionine-binding lipoprotein metQ precursor (Outer membrane lipoprotein1) | Â | Inorganic ion transport and metabolism |
sa_c350s191_a_at | SA0849 | 8.12E-05 | -2.1 | Â | Â | oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (oppA-2) | Â | Amino acid transport and metabolism |
sa_c352s195_a_at | SA0850 | 0.000757 | -3.4 | Â | Â | periplasmic oligopeptide-binding protein of oligopeptide ABC transporter | Â | Amino acid transport and metabolism |
sa_c1820s1547_a_at | SA1200 | 0.00698 | -2.1 | Â | Â | para-aminobenzoate synthetase glutamine amidotransferase component II | Â | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c1828s1551_a_at | SA1201 | 0.000803 | -2.8 | Â | Â | pir|AE0653 anthranilate synthase component II, | trp D | Amino acid transport and metabolism |
sa_c1832s1558_a_at | SA1202 | 0.00239 | -4.5 | Â | Â | anthranilate synthase; indole-glycerol phosphate synthase; | trp C | Amino acid transport and metabolism |
sa_c1836s1562_at | SA1203 | 0.00279 | -4.3 | Â | Â | indole-3-glycerolphosphate synthetase | trp F | Amino acid transport and metabolism |
sa_c1840s1566_a_at | SA1204 | 0.000663 | -3.6 | Â | Â | tryptophan synthase beta chain; tryptophan synthase (beta subunit) | trp B | Amino acid transport and metabolism |
sa_c1844s1570_a_at | SA1205 | 5.52E-05 | -2.6 | Â | Â | tryptophan synthase alpha chain; tryptophan synthase | trp A | Amino acid transport and metabolism |
sa_c1866s1587_a_at | SA1211 | 0.000158 | -2.3 | Â | Â | ATP-binding ABC transporter protein | opp-2F | Amino acid transport and metabolism |
sa_c4209s3561_a_at | SA1858 | 0.000144 | -6.2 | Â | Â | dihydroxy-acid dehydratase (DAD) | ilv D | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c4213s3565_a_at | SA1859 | 0.000431 | -8.0 | Â | Â | acetolactate synthase isozyme III large subunit (AHAS-III) | ilv B | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c9931s8627_a_at | SA1861 | 0.000255 | -10.3 | Â | Â | ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) | ilv C | Amino acid transport and metabolism, Coenzyme metabolism |
sa_c4223s3575_a_at | SA1862 | 4.06E-05 | -9.8 | Â | Â | 2-isopropylmalate synthase | leu A | Amino acid transport and metabolism |
sa_c4225s3576_a_at | SA1863 | 5.85E-05 | -11.0 | Â | Â | 3-isopropylmalate dehydrogenase | leu B | Energy production and conversion, Amino acid transportand metabolism |
sa_c4229s3580_a_at | SA1864 | 1.39E-05 | -13.2 | Â | Â | 3-isopropylmalate dehydratase large subunit | leu C | Amino acid transport and metabolism |
sa_c4239s3588_a_at | SA1865 | 6.09E-05 | -13.1 | Â | Â | 3-isopropylmalate dehydratase small subunit | leu D | Amino acid transport and metabolism |
sa_c4243s3594_a_at | SA1866 | 1.58E-05 | -7.3 | Â | Â | threonine dehydratase biosynthetic (Threonine deaminase) (TD) | ilv A | Amino acid transport and metabolism |
sa_c9447s10370cs_s_at | SA2464* | 0.00225 | -10.5 | Â | Â | histidine biosynthesis bifunctional protein | his I | Amino acid transport and metabolism |
sa_c6696s10090cs_s_at | SA2465* | 0.00199 | -10.6 | Â | Â | Imidazole glycerol phosphate synthase subunit hisF | his F | Amino acid transport and metabolism |
sa_c6706s5846_a_at | SA2466* | 0.00148 | -14.5 | Â | Â | phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase | Â | Amino acid transport and metabolism |
sa_c6708s5850_a_at | SA2467 | 0.00213 | -14.6 | Â | Â | Imidazole glycerol phosphate synthase subunit hisH | his H | Amino acid transport and metabolism |
sa_c6714s5853_a_at | SA2468* | 0.00639 | -13.6 | Â | Â | Imidazoleglycerol-phosphate dehydratase (IGPD) | his B | Amino acid transport and metabolism |
sa_c6718s5857_a_at | SA2469 | 0.00106 | -19.8 | Â | Â | histidinol-phosphate aminotransferase | Â | Amino acid transport and metabolism |
sa_c6728s5871_a_at | SA2472 | 0.0059 | -14.5 | Â | Â | ATPphosphoribosyltransferase regulatory subunit | his Z | Amino acid transport and metabolism |
sa_c6740s5882_a_at | SA2475 | 0.000217 | -6.6 |  |  | ABC transporter membrane-spanning permease – unknown substrate |  | Inorganic ion transport and metabolism |
sa_c5397s4673_a_at | SA2476 | 0.000459 | -7.6 | Â | Â | putative ABC transporter; ATP-binding protein; possible cobalt transport system | Â | Inorganic ion transport and metabolism |
Group VI: No change (20 min) – Downregulation (60 min) 19 genes | ||||||||
sa_c2346s1974_a_at | SA0144 | Â | Â | 4.02E-05 | -3.1 | capsular polysaccharide synthesis enzyme Cap5A | cap A | Cell envelope biogenesis, outer membrane |
sa_c2385s1987_a_at | SA0145 | Â | Â | 4.55E-06 | -2.9 | capsular polysaccharide synthesis enzyme Cap5B | cap B | Cell division and chromosome partitioning |
sa_c2399s1991_a_at | SA0146 | Â | Â | 0.00055 | -2.6 | capsular polysaccharide synthesis enzyme Cap8C | cap C | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2413s1997_a_at | SA0147 | Â | Â | 0.0001 | -2.6 | capsular polysaccharide synthesis enzyme Cap5D | cap D | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c9546s8318_a_at | SA0148 | Â | Â | 9.77E-05 | -2.8 | putative UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose 4-epimerase) | cap E | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2479s2056_a_at | SA0149 | Â | Â | 2.40E-06 | -3.1 | capsular polysaccharide synthesis enzyme Cap5F | cap F | Cell envelope biogenesis, outer membrane, Carbohydrate transport and metabolism |
sa_c2516s2092_a_at | SA0150 | Â | Â | 5.92E-05 | -2.4 | UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc-2-epimerase) | cap G | Cell envelope biogenesis, outer membrane |
sa_c10086s8810_a_at | SA0151 | Â | Â | 0.00025 | -2.8 | chloramphenicol acetyltransferase (Xenobiotic acetyltransferase) (XAT) | cap H | General function prediction only |
sa_c10087s8814_a_at | SA0152 | Â | Â | 0.00017 | -2.7 | capsular polysaccharide synthesis enzyme Cap5I | cap I | Cell envelope biogenesis, outer membrane |
sa_c10089s8822_a_at | SA0154 | Â | Â | 0.00103 | -2.1 | capsular polysaccharide synthesis enzyme Cap5K | cap K | Cell envelope biogenesis, outer membrane |
sa_c898s698_a_at | SA0977 | Â | Â | 0.00044 | -2.7 | 29-kDa cell surface protein | isd A | Cell envelope biogenesis, outer membrane |
sa_c906s704_a_at | SA0978 | Â | Â | 0.00538 | -2.2 | hypothetical protein SirD | isd C | Cell envelope biogenesis, outer membrane |
sa_c3380s9339_a_at | SA1586 | Â | Â | 1.41E-05 | -2.4 | 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) | rib H | Coenzyme metabolism |
sa_c3387s2918_a_at | SA1587 | Â | Â | 6.15E-06 | -2.8 | probable riboflavin biosynthesis bifunctional protein | rib A | Coenzyme metabolism |
sa_c3391s2919_a_at | SA1588 | Â | Â | 3.10E-06 | -2.7 | riboflavin synthase alpha chain | rib B | Coenzyme metabolism |
sa_c3395s2925_a_at | SA1589 | Â | Â | 5.10E-07 | -3.0 | riboflavin specific deaminase | rib D | Coenzyme metabolism |
sa_c4369s3721_at | SA1894 | Â | Â | 0.000661 | -2.3 | thiamine-phosphate pyrophosphorylase | thi E | Coenzyme metabolism |
sa_c4373s3725_a_at | SA1895 | Â | Â | 3.05E-05 | -2.5 | hydroxyethylthiazole kinase | thi M | Coenzyme metabolism |
sa_c4379s3726_a_at | SA1896 | Â | Â | 0.000137 | -2.8 | bifunctional enzyme: hydroxy-phosphomethylpyrimidine kinase | thi D | Coenzyme metabolism |
Group VII: Downregulation (20 min) – Upregulation (60 min) 3 genes | ||||||||
sa_c9442s8255_a_at | SA2459* | 0.0016 | -2.5 | 0.0016 | 2.5 | intercellular adhesion protein IcaA | ica A | Cell envelope biogenesis, outer membrane |
sa_c6677s5830_a_at | SA2460* | 0.0136 | -2.0 | 0.0136 | 4.7 | IcaD | ica D | Cell envelope biogenesis, outer membrane |
sa_c6681s9106_a_at | SA2461* | 3.83E-06 | -2.1 | 3.83E-06 | 3.4 | intercellular adhesion protein IcaB | ica B | Cell envelope biogenesis, outer membrane |