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Table 2 A-E: Cross-species overlap of biological themes (GO-terms) and single genes expressed as absolute numbers (in brackets) or percentages of human genes or GO-terms overlapping with murine.

From: Cross-species comparison of biological themes and underlying genes on a global gene expression scale in a mouse model of colorectal liver metastasis and in clinical specimens

A

Single Genes (A-Type Analysis)

Murine

L

LI

TI

T

Human

    
 

% (487 ± 0)

% (356 ± 77.8)

% (642 ± 19.8)

% (378 ± 2.8)

L (491 ± 49.5)

27.9 (137 ± 7)

4.8 (23.5 ± 2.1)

1.6 (8 ± 2.8)

1.2 (26 ± 1.4)

LI (171 ± 1.0)

9.9 (17 ± 4.2)

3.5 (6 ± 5.6)

9.0 (15.5 ± 10.6)

4.7 (8 ± 2.8)

TI(117 ± 9.9)

2.6 (3 ± 1.4)

1.7 (2 ± 1.4)

13.2 (15.5 ± 3.5)

8.2 (9.5 ± 0.7)

T (202 ± 78.5)

1 (2 ± 0)

2.8 (5 ± 0.7)

6.7 (13.5 ± 6.3)

2.0 (4 ± 2.8)

B

Single Genes (B-Type Analysis)

Murine

L

LI+TI

T

 

Human

    
 

% (1649 ± 12)

% (3287 ± 216)

% (3089 ± 1220)

 

L (1228 ± 257)

44 (539 ± 50)

32 (394 ± 82)

9.3 (114 ± 42)

 

LI+TI (2412 ± 786)

16.7 (403 ± 42)

36.5(880 ± 295)

26 (621 ± 194)

 

T (2603 ± 555)

9.7 (252 ± 59)

40.7 (1060 ± 98)

34.6(902 ± 139)

 

C

Single Genes (C-Type Analysis)

Murine

L

LI

TI

T

Human

    
 

% (7371 ± 490)

% (7909 ± 852)

% (8360 ± 238)

% (7216 ± 116)

L (491 ± 49.5)

68.6(337 ± 36)

69.0 (339 ± 50)

59.7(293 ± 33)

51.5(253 ± 39)

LI (171 ± 1.0)

52.6(90 ± 53)

60.8 (104 ± 70)

60.8(104 ± 61)

55.5(95 ± 59)

TI (117 ± 9.9)

68.4(80 ± 7)

71.0 (83 ± 13)

79.5(93 ± 7)

71.0(83 ± 35)

T (202 ± 78.5)

37.1(75 ± 20)

42.0 (85 ± 21)

44.5(90 ± 36)

38.1(77 ± 29)

D

Biological Themes (A-Type Analysis)

Murine

L

LI

TI

T

Human

    
 

% (277 ± 2)

% (5 ± 4)

% (76 ± 26)

% (51 ± 1.4)

L (458 ± 42)

28.0 (128 ± 7.8)

0.28 (1 ± 1.4)

2.0 (9 ± 6.4)

1.7 (8 ± 1.4)

LI (133 ± 11)

24.8 (33 ± 0)

0 (0 ± 0)

16.5(22 ± 1.4)

0.8 (1 ± 0)

TI (46 ± 31)

19.5 (9 ± 3.5)

0 (0 ± 0)

10.9 (5 ± 7)

10.9 (5 ± 1.4)

T (11 ± 15)

27.2 (3 ± 4)

0 (0 ± 0)

45.5 (5 ± 0)

0 (0 ± 0)

E

Biological Themes (B-Type Analysis)

Murine

L

LI+TI

T

 

Human

    
  

% (315 ± 20.5)

  

L

nd

 

nd

 

LI+TI (97 ± 11.3)

 

53 (51.5 ± 5)

  

T

nd

 

nd

 
  1. The total number of up-regulated genes or over-represented GO-terms for each compartment is indicated in the first column (human) and the first line (murine) of each panel. Experiments in duplicates. Values of particular importance are in bold font (syn-compartmental comparisons) or underlined (cross-compartmental comparisons).
  2. A-type analysis: Genes for interspecies comparison were selected according to the following criterion: Genes up-regulated in one particular compartment as compared to all other three compartments (truly compartment specific genes)
  3. B-Type analysis: Criterion: Liver compartment: Up-regulated in liver as compared to tumor. Tumor compartment: Up-regulated in tumor as compared to liver. Liver invasion plus tumor invasion compartments: Combination of genes up-regulated in LI versus L and gene up-regulated in TI versus T.
  4. C-type analysis: Criterion: Up-regulated in human compartments, present in murine compartments.