Figure 3
Conservation analysis of SLiMs recognized by SH2, SH3, PDZ and S/T kinase domains in different protein functional classes. (A) Conservation analysis of potential SH2 binding Tyr-SLiMs in cell cycle control proteins, receptor kinases/phosphatases and reported SH2 binding partners. The PLC-gamma-1 N terminal SH2 domain is shown as an example (left panel). The x-axis represents the selectivity of the PLC-gamma-1 N terminal SH2 domain, and the y-axis indicates the logarithm of CR. The Mann-Whitney test was performed to calculate the significance of the increase of conservation between SH2 non-selected (selectivity value < 5) and selected (selectivity value ≥5) Tyr-SLiMs. A color-coded map of p-values is shown on the right. (B) Conservation analysis of SLiMs recognized by SH2, SH3, PDZ and S/T kinase domains in different protein functional groups. Color-coded maps of p-values are shown below.