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Table 4 Up- or down-regulation of proteins in human iDCs in response to treatment with [BF/S+L/Ep] or cichoric acid

From: Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells

Protein Name

Protein Expression Ratio: Phytocompound Treated/Control (in 0.1% DMSO, Untreated)

Accession Number (SwissProt Data Base)

 

[BF/S+L/Ep] (75 ug/ml)

Cichoric Acid (50 ug/ml)

 
 

12 h

24 h

12 h

24 h

 

Up-regulation in protein expression

Gelsolin

1.12

1.1

2.37

5.09

P06396

Macrophage capping protein

1.39

1.13

1.31

1.34

P40121

Actin-related protein 3

0.97

1.04

1

1.23

P61158

Coronin-1C

2.55

0.71

1.74

1.1

Q9ULV4

Beta adducing

1.1

1.49

1.34

1.69

P35612

Rho GDP-dissociation inhibitor 1

0.94

1.16

0.83

1.49

P52565

Rab GDP dissociation inhibitor beta

0.9

1.37

0.88

1.46

P50395

T-complex protein 1, epsilon subunit

1.29

1.03

1.17

1.44

P48643

Serum albumin [Precursor]

1.24

1.1

1.23

0.87

P02768

Vimentin

2.44

0.77

1.1

0.7

P08670

Protein disulfide-isomerase A3 [Precursor]

1.09

1.21

0.93

1.03

P30101

Carbonic anhydrase II

1.76

1.16

1.32

1.01

P00918

Catalase

1.14

1.21

1.28

1

P04040

Superoxide dismutase [Mn], mitochondrial

1.72

1.23

1.09

0.84

P04179

Peroxiredoxin 6

1

1.13

1.1

1.31

P30041

Biliverdin reductase A [Precursor]

1.21

1.05

1.32

1.27

P53004

Poly(rC)-binding protein 1

0.87

1

0.79

1.31

Q15365

WD-repeat protein 1

1.54

1.17

1.74

1.47

O75083

TFIIH basal transcription factor complex helicase subunit

0.88

1.06

0.86

1.36

P18074

Chloride intracellular channel protein 1

0.98

1.04

0.94

1.32

O00299

Potassium voltage-gated channel subfamily H member 5

0.89

1.07

1.14

1.68

Q8NCM2

Down-regulation in protein expression

Cofilin, non-muscle isoform

0.75

0.84

0.09

0.42

P23528

F-actin capping protein beta subunit

0.99

1.09

0.87

1.23

P47756

Actin-related protein 2/3 complex subunit 2

0.83

0.53

0.94

0.58

O15144

Profilin-1

0.84

0.76

0.6

0.51

P07737

Lamin A/C

0.81

0.69

0.45

0.76

P02545

Phosphoglycerate mutase 1

1.3

0.83

0.89

1.76

P18669

Superoxide dismutase [Cu-Zn]

0.84

0.99

0.78

1.48

P00441

Dihydrolipoyl dehydrogenase, mitochondrial [Precursor]

0.97

0.61

1.12

0.82

P09622

Galactose mutarotase

1.08

1.05

1.32

1.46

Q96C23

Delta3, 5-delta2, 4-dienoyl-CoA isomerase, mitochondrial [Precursor]

1.24

0.84

1.23

0.22

Q13011

Dihydropyrimidinase related protein-2

0.96

1.22

0.77

1.74

Q16555

26S proteasome non-ATPase regulatory subunit 13

0.94

1.32

0.95

1.42

Q9UNM6

60S acidic ribosomal protein P0

1.07

1.02

0.7

1.13

P05388

Heterogeneous nuclear ribonucleoprotein H

1

0.7

0.74

0.52

P31943