Figure 3

Annotation of pri-let-7i. (a) Transcription features mapped in the flanking regions surrounding let-7i in human; (b) Predicted promoter and insulator associated regulatory regions upstream of pri-let-7i and the corresponding tiling array and UCSC conservation scores; (c) RNAalifold-predicted secondary structure of pri-let-7i. The pairs conserved in human, mouse and rat are marked in red. The hairpin precursor and the mature sequence are boxed. The Drosha cleavage sites are marked by a dashed black arrow. The stem segments and basal single-stranded regions immediately flanking the pre-miRNA are highlighted in blue.