Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation

BMC Genomics

Table 5 Orthologs of yeast buffering and non-buffering two-gene families

	Buffering pairs	Non-buffering pairs
Single-gene ortholog in fly, worm or mouse (no duplicate)
- essential	11	0
- non-essential	13	3
Multi-gene orthologs in fly, worm or mouse (with duplicates)
- all duplicates essential	1	0
- all duplicates non-essential	6	0
Other (mix of the above or no information)
	24	6

This table lists the number of instances in which for the buffering and non-buffering yeast two-gene families, respectively, single or multiple orthologs were found in fly, worm or mouse and their KO-phenotype if known. Also see Table 3 for description of the data. Orthologs are divided into single-gene orthologs (no additional homologs in the organism) and multi-gene orthologs (additional paralogs). Single- or multi-gene orthologs can be essential or non-essential in the other organism.

ISSN: 1471-2164