Table 4 Predicted function and biological processes of uORF-mORF pairs in Drosophila

CG18624

Putative NADH dehydrogenase

Mitochondrial electron transport

Pfam domain; GO term designation

CG12664

ld14, fend ^b

Unknown

Neuromuscular development

[61, 62]

CG12788/CG17767^c

Tim9b^b (uORF)

Mitochondrial inner membrane translocase subunit (uORF)

Transport across mitochondrial inner membrane (uORF)

Interpro domain

CG33713/CG33714^c

Acyl-CoA binding (mORF) RNA binding (uORF)

Unknown

Interpro domain

CG3240

Rad1 ^b

Putative 3'->5' exonuclease activity

DNA repair

[63, 64]

CG9960/CG9958^c

snapin (uORF)

Putative methyltransferase (mORF) Putative Biogenesis of Lysosome-related Organelles Complex-1-like (BLOC-1-like) subunit (uORF)

Biogenesis of lysosome-related organelles (eg. melanosomes and platelet dense granules; uORF)

[65] (uORF) Interpro domain (mORF)

CG31917

TFB5 (uORF)

Putative TFIIH subunit (uORF)

Transcription and DNA repair (uORF)

[66, 67]; Interpro domain

CG31919/CG33995^c

Ankyrin repeat, protein-protein interactions

Target of transcription factor Glial cells missing (Gcm), involved in neuronal development and function

Interpro domain; [68]

CG18042

lmg ^b

Putative component of Anaphase Promoting Complex (uORF)

Mitosis; Neural development (unclear whether it is the uORF, mORF or both)

[69, 70]; Flybase personal communication FBrf0125046; [71]; NCBI Conserved Domain Search

CG7400

Fatp ^b

Putative very-long-chain fatty acyl-CoA synthetase

Fatty acid metabolism

[72]

CG16974

Member of LIG superfamily^b

Leucine-rich repeat and Immunoglobulin domain-containing protein

Unknown

[73, 74]

CG4824

BicC ^b

RNA binding protein

Anterior-Posterior patterning

[75–77]

CG17325

Unknown

Unknown

CG10570

Unknown

Unknown

CG11508

DmSNAP50, DmPBP49 ^b

Subunit of an snRNA transcriptional activator protein

Transcription of splicing factors

[78]

CG8026

Mitochondrial carrier protein

Mitochondrial folate transport

[37, 38]

CG17759^b (uORF2)

Galpha49B, Gqα ^b

G-protein subunit

Photoreceptor signal transduction; Axonal guidance

[79–81]

CG33671/CG33672^c

Mevalonate kinase (mORF); BolA-like protein, putative nucleic acid binding protein (uORF)

Isoprenoid production (mORF)

[82, 83]

CG6191

Unknown

Unknown

CG30100

Translation release factor

Translation termination

GO term designation

CG17725

Pepck ^b

Putative phosphoenolpyruvate carboxykinase

Gluconeogenesis; Starvation; Glyceroneogenesis

[84–86]

CG5469

Gint3 ^b

Ubiquitin regulatory X domain (UBX), putative RNA binding

Unknown

[87]; FBrf0189302

CG33786/CG33785^c

Unknown

Translation (mORF) Transcription (uORF)

Interpro domain

CG9865^b (uORF1)

Putative mannosyl transferase

Unknown

Interpro domain

CG9865^b (uORF2)

Putative mannosyl transferase

Unknown

Interpro domain

CG9865^b (uORF3)

Putative mannosyl transferase

Unknown

Interpro domain

CG9878

Tim10 ^b

Putative inner mitochondrial membrane translocase

Protein transport across mitochondrial membrane

[88]

CG30290

Putative flavoprotein enzyme

Unknown

Interpro domain

CG12016

Unknown

Unknown

CG32573

Unknown

Unkown

CG11989

Ard1 ^b

Putative N-Acetyltransferase catalytic subunit

Unknown

[89]; Interpro domain

CG7869

SuUR ^b

DNA binding

Endoreplication

[90, 91]

CG7628

Phosphate transporter

Phosphate transport

Interpro domain

CG9666

Putative methyltransferase

Unknown

Interpro domain

CG2128

Hdac3 ^b

Histone deacetylase

Wing development; Chromatin remodeling

[92, 93]

CG9288

Pyruvate kinase

Unknown

Interpro domain

CG9924

Rdx ^b

Unknown

Regulator of Hedgehog response (growth and development)

[94, 95]

CG31241

DTL ^b

Putative RNA methylase

Late larval development

[24]; Interpro domain

CG31178

Unknown

Unknown

CG7071/CG34131^c

Unknown

Unknown

CG10238

MOCS2 ^b

Molybdopterin synthase large subunit (mORF) and small subunit (uORF)

Production of molybdopterin; Implicated in mammalian neurological damage

[23, 96]

CG5116

Putative GTP-binding protein

Unknown

Interpro domain

CG14550

Putative phosphatidylinositol N-acetylglucosaminyltransferase subunit P (mORF); Pcc1-like transcription factor (uORF)

Unknown

Interpro domains

CG7950

Putative tRNA processing enzyme subunit (uORF)

tRNA processing (uORF)

Interpro domain