Table 3 miRNAs and their targets

miR-128

ABCB9, BTG1, DSCR1, RASD1

ABC transporters General

miR-136

GRN, PPP1R9B

miR-147

HOXA1, PTGFRN

miR-148

EGR3, SCN3A

miR-181b

IGF1R, NKX6-1

Adherens junction, Maturity onset diabetes of the, Focal adhesion, **Long term depression

miR-196a

ABCB9, CPB2, IRS1, MAPK10

ABC transporters General, Complement and coagulation cas, Adipocytokine signaling pathwa, Insulin signaling pathway, Type II diabetes mellitus, Fc epsilon RI signaling pathwa, Focal adhesion, **GnRH signaling pathway, **MAPK signaling pathway, Toll like receptor signaling p, Wnt signaling pathway

miR-203

SARA1

miR-20

BTG1, SARA1, YWHAB

Cell cycle

miR-21

TPM1

mir-216

GNAZ

**Long term depression

miR-217

RHOA

Adherens junction, Axon guidance, Focal adhesion, Leukocyte transendothelial mig, Regulation of actin cytoskelet, TGF beta signaling pathway, T cell receptor signaling path, Tight junction, Wnt signaling pathway

miR-31

ATP2B2, DNM1L, EGR3, PPP1R9B, YWHAB

**Calcium signaling pathway, Cell cycle

miR-7

SLC23A2

miR-7b

HRH3, NCDN, SLC23A2

**Neuroactive ligand receptor in

b: miRNAs and their targets (from TargetScan and miRanda). miRNAs and their corresponding targets are both differentially regulated during PKD.

miRNA

Target Genes

Pathways

miR-128

ABCB9, BTG2, CACNB2, CNR1, COL3A1, GLRA2, IRS1, NEK6, PDE7B, PTPN5, SV2A, SYT4, YWHAB, NR5A2, NTRK3

ABC transporters General, **MAPK signaling pathway, **Neuroactive ligand receptor in, **Cell Communication, **ECM receptor interaction, Focal adhesion, Adipocytokine signaling pathwa, Insulin signaling pathway, Type II diabetes mellitus, Purine metabolism, Cell cycle, Maturity onset diabetes of the

miR-136

KCNH7

miR-148

OTX1, YWHAB

Cell cycle

miR-181b

ADAMTS1, ATP2B2, CACNB2, CDH13, CNR1, DUSP6, EGR3, EPHA7, GRIK2, GRM5, GRM7, HOXA1, MMP14

**Calcium signaling pathway, **MAPK signaling pathway, **Neuroactive ligand receptor in, Axon guidance, Gap junction, **Long term depression, Long term potentiation, **GnRH signaling pathway

miR-196a

ABCB9, COL3A1, EPHA7, GAS7, OTX1

ABC transporters General, **Cell Communication, **ECM receptor interaction, Focal adhesion, Axon guidance

miR-203

TGFB3

Cell cycle, **MAPK signaling pathway, TGF beta signaling pathway

miR-21

BTG2

miR-217

CLU, FN1, GRIK2, KCNH5, NR4A2, RAP1B

**Cell Communication, **ECM receptor interaction, Focal adhesion, Regulation of actin cytoskelet, **Neuroactive ligand receptor in, Leukocyte transendothelial mig, Long term potentiation, **MAPK signaling pathway

miR-302b*

ATP2B2

**Calcium signaling pathway

miR-302c

ATP2B2, CNR1, SNF1LK

**Calcium signaling pathway, **Neuroactive ligand receptor in

miR-302c*

ATP2B2, SNF1LK

**Calcium signaling pathway

miR-30a-3p

CCKBR, COLEC12, EPHA7, GRM7, JUN, KCNAB1, LIN7A, MAMDC1, PRRX1

**Calcium signaling pathway, **Neuroactive ligand receptor in, Axon guidance, B cell receptor signaling path, Focal adhesion, **GnRH signaling pathway, **MAPK signaling pathway, T cell receptor signaling path, Toll like receptor signaling p, Wnt signaling pathway

miR-346

GRM7, LTBP2

**Neuroactive ligand receptor in

miR-372

ATP2B2, NR4A2, SNF1LK, RET, SLC11A2

**Calcium signaling pathway

miR-448

COLEC12, DNM3, GRIK2, IGF1R, IL12B, KCNH7, KCNIP4, SCN3A, SCN5A

**Neuroactive ligand receptor in, Adherens junction, Focal adhesion, **Long term depression, **Cytokine cytokine receptor int, **Jak STAT signaling pathway, Toll like receptor signaling p, **Type I diabetes mellitus

miR-34b

BTG2, CALCR, DLL1, MYRIP

**Neuroactive ligand receptor in, Notch signaling pathway

miR-380-3p

BCL2L1

Amyotrophic lateral sclerosis, Apoptosis, **Jak STAT signaling pathway, Neurodegenerative Disorders

miR-7b

EGR3