Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus

BMC Genomics

Table 2 Potentially functionally significant amino acid variants

Gene	Amino Acid	MM	MS	HS	RN	GG	BT	CF	XT	MD	TR	SIFT
Slc26a3	His38Asn	His	Asn	His	His	His	His	His	His	His	His	0.13
Dus4L	Cys104Tyr	Cys	Tyr	Cys	Cys	Asn	Cys	Cys	Ser	Cys	Ala	0.18
Cog5	Ser769Ala	Ser	Ala	Ser	Ser	Ser	Ser	Ser	NH	Ser	Ser	0.09
1110049B09Rik	Pro691Ala	Pro	Pro/Ala	Pro	Lys	Pro	Pro	Pro	Pro	Pro	NH	0.11
F730043M19Rik	Asn133Ile	Asn	Ile/Asn	NH	NH	NH	NH	NH	NH	NH	NH	0.00
4930504H06Rik	Met64Val	Met	Val	Met	Met	NH	Met	Met	NH	Met	Phe	0.13
Ahr	Leu348Phe	Leu	Phe	Leu	Leu	Leu	Leu	Leu	Leu	Leu	Leu	0.01
	Ser790Gly	Ser	Gly	Asn	Ser	Asp	Asn	Asn	Asn	His	NH	0.15
Ankmy2	Ile369Thr	Ile	Thr	Ile	Thr	Leu	Leu	Leu	Glu	Leu	NH	0.03
Sostdc1	Cys15Ser	Cys	Ser	Cys	Cys	Cys	Cys	Cys	Cys	Cys	Cys	0.00
Ifrd1	Leu449Phe	Leu	Phe	Phe	NH	Phe	Phe	Phe	Leu	Phe	Phe	0.00
EG629820	Gly47Ser	Ser	Ser/Gly	NH	NH	NH	NH	NH	NH	NH	NH	0.00
	Gly70Ser	Gly	Ser/Gly	NH	NH	NH	NH	NH	NH	NH	NH	0.00
	Asn72Tyr	Asn	Tyr/Asn	NH	NH	NH	NH	NH	NH	NH	NH	0.00
Zfp277	Val21Phe	Val	Val/Phe	Ser	NH	NH	Asp	Asp	NH	NH	NH	0.08
	Gln43His	Gln	Gln/His	Gln	NH	Gln	Gln	Gln	Gln	Gln	Gln	0.15
Immp2L	Ala8Val	Ala	Val	Val	Val	Gly	Val	Val	NH	Gly	Gly	0.15
Lrrn3	Ala69Gln	Ala	Ala/Gln	Ala	Ala	Ala	Ala	Ala	NH	Ala	Leu	0.08
	Ala671Val	Ala	Ala/Val	Ala	Ala	Ser	Ala	Thr	NH	Ala	NH	0.15
Stxbp6	Ile23Val	Ile	Val	Val	Val	Val	NH	Val	Val	Val	Val	0.12

Bold indicates significant SIFT scores. No known homology (NH), Mus musculus (MM), Mus spretus (MS), Homo sapiens (HS), Rattus norvegicus (RN), Gallus gallus (GG), Bos Taurus (BT), Canis familiaris (CF), Xenopus tropicalis (XP), Monodelphis domestica (MD), and Takifugu rubripes (TR). Sift scores in bold are predicted to be non-tolerated changes.

ISSN: 1471-2164