Human and mouse switch-like genes share common transcriptional regulatory mechanisms for bimodality

BMC Genomics

Table 4 KEGG pathways enriched for bimodal genes with "high" or "low" expression within brain, heart, and skeletal muscle tissues in human and mouse.

	Brain		Heart		Skeletal Muscle
	Human	Mouse	Human	Mouse	Human	Mouse
Calcium signaling pathway					high
Carbon fixation			high	High	high
Cell Communication	low	low	high	High		high
Cell adhesion molecules (CAMs)					low
Citrate cycle (TCA cycle)				high	high
ECM-receptor interaction	low	low	high	high	high	high
Focal adhesion	low	low	high	high	high	high
Gap junction	high	high		low	low	low
Glycolysis/Gluconeogenesis			high	high	high	high
Insulin signaling pathway				high
Leukocyte transendothelial migration						high
Long-term depression	high		low	low	low	low
Long-term potentiation		high	low
Neurodegenerative Diseases	high
Pyruvate metabolism			high	high	high
Reductive carboxylate cycle (CO2 fixation)			high		high
Regulation of actin cytoskeleton						high
Type I diabetes mellitus					low

The mode of expression is indicated for tissue types where pathways are significantly enriched for the set of bimodal genes in the "high" mode or the set of bimodal genes in the "low" mode of expression. Significance was determined from a hypergeometric distribution with cutoff p = 0.05.

ISSN: 1471-2164