Up regulation in gene expression of chromatin remodelling factors in cervical intraepithelial neoplasia

BMC Genomics

Table 1 Genes differentially expressed in Networks A and B.

Network	IPA Score*	Increased in CIN III	Decreased in CIN III
A	22	BH3 interacting domain death agonist	cyclin-dependent kinase inhibitor 2B
		cytochrome b-561	Cbp/p300-interacting transactivator, with
		dihydrofolate reductase	Glu/Asp-rich carboxy-terminal domain, 2
		nuclear receptor co-repressor 1	endothelin 3
		sialidase 1	interferon-related developmental regulator 1
		peptidyl-prolyl cis/trans isomerase, NIMA-	Kruppel-like factor 6
		interacting	phosphatase and tensin homolog RAB4A
		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	retinoblastoma-like 2 (p130)
B	17	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	adaptor-related protein complex 3, mu 2 subunit
		B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	cyclin-dependent kinase inhibitor 2B cellular repressor of E1A-stimulated genes 1
		creatine kinase, brain	Kruppel-like factor 6
		mortality factor 4 like 2	keratin 17
		Mof4 family associated protein 1	tropomodulin 3
		ribophorin I
		stomatin (EPB72)-like 2

* The score is a numerical value used to rank networks according to how relevant they are to the genes in your input dataset. Calculations are based on the hypergeometric distribution calculated via the computationally efficient Fisher's Exact Test for 2 × 2 contingency tables⁸. Gene symbols in bold denote those selected for validation in a new panel of fourteen cases.

ISSN: 1471-2164