Table 3 Differentially expressed genes in the mouse liver after phenobarbital treatment (Sterolgene v0 microarray). Differentially expressed genes in the mouse liver after phenobarbital treatment as detected by the Sterolgene array (α = 0.1).
Gene name and function | Gene symbol | Log2 ratio | GeneBank Acc. No. |
|---|---|---|---|
Cytochrome P450 superfamily – xenobiotic metabolism | |||
Cytochrome P450, 1a2 | Cyp1a2 | 0.57* | NM_009993 |
Cytochrome P450, 2a4 | Cyp2a4 | 1.89* | BC011233 |
Cytochrome P450, 2b10 | Cyp2b10 | 9.14* | AK028103 |
Cytochrome P450, 2b13 | Cyp2b13 | 9.94* | NM_007813 |
Cytochrome P450, 2c40 | Cyp2c40 | 0.79 | NM_010004 |
Cytochrome P450, 2f2 | Cyp2f2 | -0.54* | NM_007817 |
Cytochrome P450, 3a25 | Cyp3a25 | 2.09* | BC028855 |
Cytochrome P450, 3a41 | Cyp3a41 | 3.24* | NM_017396 |
Cytochrome P450 superfamily – endogene metabolism | |||
Retionic acid hydrolase | Cyp26a1 | -0.72* | NM_007811 |
Thromboxane A synthase 1 | Cyp5a1 | -1.11 | NM_011539 |
Cytochrome P450, 7b1 | Cyp7b1 | -0.88 | BC038810 |
Nuclear receptors superfamily | |||
Constitutive androstane receptor | Nr1i3 | 3.51* | NM_009803 |
Testis receptor | Nr2c1 | -0.67* | NM_011629 |
Glucocorticoid receptor | Nr3c1 | 1.84* | NM_008173 |
Transporters | |||
Ileal sodium-dependent bile acid transporter | Slc10a2 | -1.55* | NM_011388 |
Heme metabolism | |||
Delta-aminolevulinate synthase 1 | Alas1 | 3.36* | NM_020559 |