Table 1 p53-miRs (microRNAs which have a conserved p53 binding site in their flanking 10 kb genomic sequence) which putatively target known transcription factors that are either upstream or downstream to p53 network (based on p53 knowledge base [36]) (A: activator; R: Repressor; U: uncharacterized). Only those targets are shown that are predicted as miRNA targets by 2 or more than two algorithms. miRNAs that are in bold represent miRNAs induced more than 1.5 fold (p < 0.05) after p53 activation [11]. The last column indicates whether a miRNA has been reported in literature as differentially expressed in cancer or cancer cell lines.
From: Dissecting microregulation of a master regulatory network
miRNA | TF | TargetScanS | miRanda | microT | miRtarget | picTar | Relation to p53 (Interaction Type) [20] | Differentially expressed in cancer |
|---|---|---|---|---|---|---|---|---|
hsa-miR-183 | EGR1 | + | + | - | + | - | Upstream (A) | Yes |
hsa-miR-26b | HOXA5 | + | - | - | + | - | Upstream (A) | Yes |
hsa-miR-96 | HOXA5 | + | - | - | + | - | Upstream (A) | Yes |
hsa-miR-376a | HOXA5 | - | + | + | - | - | Upstream (A) | No |
hsa-miR-376b | HOXA5 | - | + | + | - | - | Upstream (A) | No |
hsa-miR-181c | FOS | + | + | - | + | - | Upstream (A/R) | Yes |
hsa-miR-222 | FOS | + | + | - | - | - | Upstream (A/R) | Yes |
hsa-miR-101 | FOS | + | + | - | + | - | Upstream (A/R) | No |
hsa-miR-10a | BCL6 | + | + | - | - | - | Upstream (R) | Yes |
hsa-miR-124a | KLF4 | + | - | - | + | - | Upstream (R) | Yes |
hsa-miR-148a | KLF4 | + | + | + | + | - | Upstream (R) | Yes |
hsa-miR-32 | KLF4 | + | + | - | + | - | Upstream (R) | Yes |
hsa-miR-34a | KLF4 | + | - | - | + | - | Upstream (R) | Yes |
hsa-miR-7 | KLF4 | + | - | - | + | - | Upstream (R) | Yes |
hsa-miR-508 | KLF4 | - | + | - | + | - | Upstream (R) | No |
hsa-miR-155 | CEBPB | + | + | + | - | - | Upstream (U) | Yes |
hsa-miR-27a | BTG2 | + | + | + | - | - | Downstream (A) | Yes |
hsa-miR-32 | BTG2 | + | + | - | - | - | Downstream (A) | Yes |
hsa-miR-27a | CCNG1 | + | - | - | + | - | Downstream (A) | Yes |
hsa-miR-122a | CCNG1 | + | + | - | + | - | Downstream (A) | Yes |
hsa-miR-33 | EEF1A1 | + | + | - | - | - | Downstream (A) | No |
hsa-miR-502 | GADD45A | - | + | - | + | - | Downstream (A) | No |
hsa-miR-19b | IGFBP3 | + | + | - | - | - | Downstream (A) | Yes |
hsa-miR-29a | MMP2 | - | + | - | + | - | Downstream (A) | Yes |
hsa-miR-29b | MMP2 | - | + | - | + | - | Downstream (A) | Yes |
hsa-miR-29c | MMP2 | - | + | - | + | - | Downstream (A) | Yes |
hsa-miR-128b | PLK2 | + | + | - | + | + | Downstream (A) | Yes |
hsa-miR-200b | PLK2 | + | + | - | + | - | Downstream (A) | Yes |
hsa-miR-200c | PLK2 | + | + | - | + | - | Downstream (A) | Yes |
hsa-miR-27a | PLK2 | + | + | - | + | + | Downstream (A) | Yes |
hsa-miR-30b | SERPINE1 | + | + | + | + | - | Downstream (A) | Yes |
hsa-miR-30c | SERPINE1 | + | + | + | + | - | Downstream (A) | Yes |
hsa-miR-34a | SERPINE1 | + | - | - | + | - | Downstream (A) | Yes |
hsa-miR-192 | RB1 | + | + | - | - | - | Downstream (A/R) | Yes |
hsa-miR-200b | ANLN | + | + | - | - | - | Downstream (R) | Yes |
hsa-miR-200c | ANLN | + | + | - | - | - | Downstream (R) | Yes |
hsa-miR-142-3p | IER3 | - | + | - | + | - | Downstream (R) | Yes |
hsa-miR-124a | SCD | + | - | - | + | - | Downstream (R) | Yes |