Global gene expression analysis of early response to chemotherapy treatment in ovarian cancer spheroids

BMC Genomics

Table 1 Characteristics of the six OC cell lines used in the study.

Cell type	Source	Histopathology	IC50 values (μM)
			cisplatin	paclitaxel	topotecan
OVCAR-3	tumor	Adenocarcinoma	0,70	0,03	0,27
SKOV-3	ascites	Adenocarcinoma	7,50	0,05	0,23
OV-90	ascites	Adenocarcinoma	4,50	0,025	0,21
TOV-21	tumor	Clear cell carcinoma	2,00	0,013	1,3
TOV-112	tumor	Endometrioid carcinoma	3,50	0,016	0,25
TOV-155	tissue	Cyst adenoma^a	1,25	0,015	0,27
Treatment^b			10,0 μM	2.5 μM	5,0 μM

^aUpon cultivation, the spontaneously immortalized TOV-155 cell line exhibited typical characteristics of an OC cell line (including p53 mutations, oncogene expression and continuous growth). The complete characterization of this cell line will be reported elsewhere.
^bThe drug concentrations indicated were used for treatment of the OC spheroid cultures (details in text).

ISSN: 1471-2164