Table 6 Selected differentially expressed gene groups upon paclitaxel treatment.
A. Up-regulated genes | |
|---|---|
Apoptosis | BAG5, GULP1, BAX |
Cell cycle | SEPT10, C10orf9, TAF1L |
Cell adhesion | CELSR3, CLDN2, COL24A1, SYMPK, TNXB, CTTN, GJA10 |
Cytoskeleton | CDC42, K-ALPHA-1, TUBA1, TUBA3, TUBA4, TUBA6, TUBB, TUBB2, TUBB3, TUBB4, TUBB6 |
Metabolism | EBPL, OSBP, OSBP2, PAQR6, AMAC1L2, AOC2, ASAH2, CL640, MDH1, NDUFA4, FAM3D |
Protein biosynthesis & modification | MRPL13, RPL39, RPS29, PTP4A3, DNAJB5, MGAT2, RNF149, RNF44, TRIM21 |
Response to stress | MT2A, C2D1A, IKIP, TFG |
Signal transduction | BZRP, DUSP9, EFNA3, LPHN1, LRP6, NRAS, SNX24, STARD8, WNT10A |
Transport | ATP2B3, CNO, GRASP, KCNJ9, PRRG2, RBP4, S100A10, SLC25A17, SLC25A24, TMCO3, TPCN2, TRAM2 |
B. Down-regulated genes | |
Cell growth & proliferation | HDGF2, PDAP1, MT3, DOT1L, H2BFS, HIST1H1B, SAFB, VCX-C |
Cell cycle | PARD6G, PLK1, DDIT3, DDIT4, MXD4 |
Immune response | C1QL1, HLA-A, HLA-E, LAT, SLPI, TNFRSF13B |
Metabolism | HDLBP, PSAP, ALDOA, DHPS, DHRS10, ENO1B, G6PD, HAGHL, IMPDH2, NUDT14, PSMC3, SDHA |
Protein biosynthesis & modification | EIF4G1, MRPL12, MRPL23, RPL10L, VARS2, FLOT1, BCKDK, CKAP1, GALNT9, KIAA1542 |
Regulation of transcription | ZNF317, ZNF225, ATF5, CEBPE, DBP, ZNF665, ZFP3, ZFP41, ING5, MAF1, MBD3, NFE2L1, POLR2E, ZBTB16, ZFP276, ZNF208, ZNF214, ZNF221, ZNF257, ZNF425, ZNF432, ZNF473, ZNF511, ZNF529, ZNF583, ZNF585B, ZNF79, ZNF155 |
Signal transduction | DUSP24, ARHGEF10L, GPR172B, GPR20, GRM4, MAPK12, OR2T5, PRKCSH, RAB3D, TMEPAI |
Transport | CLTB, COX6A2, EPN1, GRPEL1, KCNJ13, SEC14L5, MGC19604, RNP24, SLC12A6, SLC37A1, TIMM44, TLOC1, ATP5B, ABCC6 |
Response to stress | MT3, GATA3, HSPA1A |