Skip to main content

Table 2 miRNA synergism results beyond consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

miRNA A

miRNA B

Borda rank

Disease A

Disease B

Literature A

Literature B

miR-106b

miR-17

1

Various diseases

Various diseases

[40]

[41]

miR-19a

miR-19b

2

Various cancer types

Various cancer types

[6,42,43]

[6,41-43]

miR-363

miR-92b

3

Alzheimers disease

Lupus nephritis

  

miR-181b

miR-181d

4

Cardiac hypertrophy

Various diseases

  

let-7d

let-7f

6

Various cancer types

Various cancer types

[44]

 

miR-18a

miR-18b

7

Various cancer types

Cardiac hypertrophy

[42]

 

miR-128

miR-27b

8

Various diseases

Cardiac hypertrophy

  

miR-106a

miR-291a-3p

9

Various diseases

 

[45]

 

miR-30a

miR-30e

100

Cardiac hypertrophy

Cardiac hypertrophy

[7,46]

[7]

miR-30e

miR-384-5p

132

Cardiac hypertrophy

 

[7]

[47]

miR-30c

miR-30e

184

Cardiac hypertrophy

Cardiac hypertrophy

[46]

[7]

miR-294

miR-30e

318

 

Cardiac hypertrophy

 

[7]

miR-291a-3p

miR-30e

364

 

Cardiac hypertrophy

 

[7]

miR-18b

miR-297c

385

Cardiac hypertrophy

   

miR-190

miR-194

391

Various cancer types

Cardiac hypertrophy

 

[28]

miR-30d

miR-30e

398

Cardiac hypertrophy

Cardiac hypertrophy

 

[7]

miR-34a

miR-34b-5p

399

Various diseases

Various cancer types

[8]

 

miR-30e

miR-495

411

Cardiac hypertrophy

Various diseases

[7]

[48]

miR-139-3p

miR-150

438

Cardiac hypertrophy

Cardiac hypertrophy

 

[28]

miR-30e

miR-466d-5p

453

Cardiac hypertrophy

 

[7]

 

miR-1

miR-18a

457

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Various cancer types

[36]

[42]

miR-187

miR-18b

460

Non-alcoholic fatty liver disease (NAFLD)

Cardiac hypertrophy

  

miR-185

miR-18b

462

Cardiac hypertrophy

Cardiac hypertrophy

  

miR-100

miR-30e

489

Various diseases

Cardiac hypertrophy

[49]

[7]

miR-1

miR-19a

492

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Various cancer types

[36]

[6,42,43]

miR-1

miR-206

512

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Various diseases

[36]

 

miR-194

miR-210

530

Cardiac hypertrophy

Various diseases

[28]

[50]

miR-192

miR-218

548

Various cancer types

Cardiac hypertrophy

[28]

 

miR-191

miR-218

549

Various cancer types

Cardiac hypertrophy

[48]

 

miR-18b

miR-219

550

Cardiac hypertrophy

Various cancer types

  

miR-18b

miR-22

552

Cardiac hypertrophy

Various diseases

 

[26,51]

miR-34a

miR-449b

563

Various diseases

Various cancer types

[8]

 

miR-150

miR-224

570

Cardiac hypertrophy

Various cancer types

[28]

 

miR-18b

miR-297b-5p

599

Cardiac hypertrophy

   

miR-150

miR-296-5p

620

Cardiac hypertrophy

Various diseases

[28]

 

miR-1

miR-29a

634

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Cardiac hypertrophy

[36]

[52]

miR-1

miR-29b

636

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Cardiac hypertrophy

[36]

[6,52]

miR-1

miR-29c

639

Cardiac hypertrophy/cardiomyopathy/heart failure/myocardial infarction/coronary artery disease

Cardiac hypertrophy

[36]

[6,52]

  1. Synergism results for miRNA pairs that ranked in the upper quartile according to Borda voting scheme but not incorporated in the consensus modules (indicative examples). Each line reports the rank of each miRNA pair, disease-related information of the human orthologs as recorded in miR2Disease database (if found only cardiac pathophysiology related terms are reported) and evidence related to aging or cardiac pathophysiology provided by recent literature. Bold miRNAs are age-dependent based on linear regression analysis. We also added miRNA pairs with high rank yet not related to aging or cardiac pathophysiology (highlighted in italics).
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us