Skip to main content

Table 3 Analysis of mouse consensus modules

From: Integromics network meta-analysis on cardiac aging offers robust multi-layer modular signatures and reveals micronome synergism

Module index

Count

Gene ontology term

Percentage

Fisher exact P-value

Age-dependent miRNAs

Age-dependent genes

GenAge genes

1

18

One-carbon metabolic process

11.8

5.0E-2

N/A

N/A

N/A

2

22

Cellular aromatic compound metabolic process

10

5.0E-2

N/A

GOS2

 

3

5

N/A

N/A

N/A

 

N/A

N/A

4

9

N/A

N/A

N/A

miR-34a

N/A

N/A

5

68

Generation of precursor metabolites and energy

73.5

1.6E-77

N/A

HADH, NDUFA10, NDUFV1

SLC25A4, UCP2

6

23

N/A

N/A

N/A

N/A

CDH22

N/A

7

4

N/A

N/A

N/A

N/A

N/A

N/A

8

5

Heart development

40

5.0E-2

N/A

N/A

N/A

9

8

N/A

N/A

N/A

N/A

NDUFA10

N/A

10

16

Tissue development

30.8

7.2E-3

N/A

N/A

EPS8

11

20

N/A

N/A

N/A

N/A

N/A

BUB1B

12

27

N/A

N/A

N/A

N/A

N/A

BUB1B, MCM2

13

24

N/A

N/A

N/A

N/A

RHOU

N/A

14

5

N/A

N/A

N/A

N/A

N/A

N/A

15

6

N/A

N/A

N/A

miR-466d-3p

IER3

N/A

16

8

N/A

N/A

N/A

N/A

N/A

N/A

17

5

N/A

N/A

N/A

N/A

N/A

N/A

18

13

N/A

N/A

N/A

miR-152

N/A

N/A

19

36

N/A

N/A

N/A

N/A

RPL10, RPL37

N/A

20

5

N/A

N/A

N/A

N/A

N/A

N/A

21

13

N/A

N/A

N/A

N/A

N/A

N/A

22

5

N/A

N/A

N/A

N/A

N/A

N/A

23

13

Response to DNA damage stimulus

53.8

1.4E-8

N/A

N/A

ERCC2

24

8

N/A

N/A

N/A

N/A

N/A

MCM2

25

6

N/A

N/A

N/A

N/A

RPA3

N/A

26

6

N/A

N/A

N/A

N/A

N/A

N/A

27

7

N/A

N/A

N/A

N/A

N/A

N/A

28

5

N/A

N/A

N/A

N/A

N/A

N/A

29

7

N/A

N/A

N/A

N/A

EEF2

N/A

30

8

N/A

N/A

N/A

N/A

N/A

N/A

31

6

N/A

N/A

N/A

N/A

N/A

N/A

32

5

N/A

N/A

N/A

N/A

N/A

N/A

33

6

N/A

N/A

N/A

miR-135a

N/A

N/A

34

4

N/A

N/A

N/A

N/A

N/A

N/A

35

28

Cellular nitrogen compound metabolic process

78.6

6.2E-12

N/A

N/A

N/A

36

25

Cellular nitrogen compound metabolic process

76

2.1E-9

N/A

N/A

N/A

37

8

N/A

N/A

N/A

N/A

N/A

N/A

38

24

N/A

N/A

N/A

N/A

N/A

N/A

39

10

N/A

N/A

N/A

N/A

N/A

MCM2

40

10

N/A

N/A

N/A

N/A

N/A

N/A

  1. Summary of the 40 consensus modules. Count: The number of module members; Gene Ontology (GO) term: Statistically significant GO terms based on DAVID tool (P-value <= 0.05); Percentage: The percentage of modular genes characterized by the specific GO term; Fisher exact P-value: modified Fisher exact P-value (EASE score) as provided by DAVID (the complete mouse genome was used as background); Age-dependent miRNAs: Age-dependent miRNAs based on linear regression analysis; Age-dependent genes: Age-dependent genes based on linear regression analysis; GeneAge genes: longevity-associated genes according to GenAge database. N/A: not available.