Table 1 GO terms related to neurological, epigenetic, and developmental processes from cluster analysis in intermediate stringency

Neurological

Expected

Observed

p-value (fdr)

Enrichment

 Neurological system process

616.197

485

2.86E-13

down

 Neurogenesis

332.402

396

7.11E-06

up

 Neuron projection

190.242

237

1.74E-05

up

 Generation of neurons

309.405

366

4.80E-05

up

 Neuron differentiation

281.183

333

0.000109238

up

 Axon

91.4627

117

0.00142957

up

 Cell morphogenesis involved in neuron differentiation

124.389

151

0.00563766

up

 Neuron projection morphogenesis

127.525

154

0.00684608

up

 Glial cell differentiation

39.721

53

0.0202685

up

 Regulation of neuron differentiation

93.0307

113

0.0215321

up

 Gliogenesis

46.5153

60

0.0317942

up

 Regulation of neurogenesis

113.414

134

0.0340942

up

Epigenetic

Expected

Observed

p-value (fdr)

Enrichment

 Protein amino acid methylation

25.0869

35

0.0332904

up

 Lysine N-methyltransferase activity

18.8152

27

0.0455873

up

 Protein-lysine N-methyltransferase activity

18.8152

27

0.0455873

up

 Histone-lysine N-methyltransferase activity

18.8152

27

0.0455873

up

 N-methyltransferase activity

29.7907

40

0.0461752

up

 Histone H2A acetylation

6.27173

11

0.0496797

up

Development

Expected

Observed

p-value (fdr)

Enrichment

 Sensory perception of smell

189.197

33

1.42E-66

down

 Sensory perception of chemical stimulus

209.58

50

3.33E-61

down

 Sensory perception

389.37

253

6.42E-22

down

 Developmental process

1748.24

1912

1.16E-08

up

 System development

1318.63

1463

2.08E-08

up

 Anatomical structure development

1460.79

1608

4.39E-08

up

 Multicellular organismal development

1593.54

1744

6.81E-08

up

 Nervous system development

603.131

699

1.78E-07

up

 Regulation of developmental process

413.934

494

1.94E-07

up

 Positive regulation of developmental process

182.925

236

3.04E-07

up

 Neuron development

205.399

249

0.000157004

up

 Forebrain development

90.4174

118

0.000419088

up

 Central nervous system development

239.371

282

0.000802517

up

 Neuron projection development

166.723

200

0.00211809

up

 Sensory organ development

129.093

154

0.0128753

up

 Regulation of nervous system development

123.344

146

0.0233886

up

 Brain development

163.588

189

0.0279154

up

 Post-embryonic development

33.4492

45

0.0307565

up

 Regulation of neuron projection development

56.4456

71

0.0355767

up

 Embryonic development

321.949

354

0.0476929

up