Age and prior blood feeding of Anopheles gambiae influences their susceptibility and gene expression patterns to ivermectin-containing blood meals

Table 4 Immunity-related transcripts differentially expressed after IVM ingestion

Gene ID	Description	Family	2IVM:2BF FC	6IVM:6BF FC
AGAP010968	Clip-Domain Serine Protease (CLIPA9)	CLIP	5.23	19.69
AGAP007142	Serine-type enodpeptidase	SRP	-	15.35
AGAP009217	Clip-Domain Serine Protease (CLIPB12)	CLIP	-	7.00
AGAP001199	serine protease	SRP	7.12	5.70
AGAP011792	Clip-Domain Serine Protease (CLIPA7)	CLIP	-	2.64
AGAP005552	peptidoglycan recognition protein (Long)	PGRP	-	2.48
AGAP012247	phosphoserine phosphatase	SC	-	2.44
AGAP004918	fibrinogen	FibR	-	2.33
AGAP007386	C-Type Lysozyme	LYS		2.29
AGAP003878	Leucine-rich repeat-transmembrane protein	Anti-parasitic	-	2.21
AGAP006416	Serine protease SP24D	SRP	-	2.14
AGAP003250	Clip-Domain serine protease (CLIPB4)	CLIP	-	2.08
AGAP008645	gambicin anti-microbial peptide	AMP	-	2.03
AGAP004916	Fibrinogen-related	FibR	-	2.02
AGAP009212	Serine Protease Inhibitor (serpin)	SRPN	-	−2.06
AGAP012045	ATP-dependent RNA helixase DDX5/DBP2	Small RNA pathway	3.49	−2.06
AGAP003139	Serine Protease Inhibitor (serpin)	SRPN	-	−2.17
AGAP001979	Class A Scavenger Receptor (SRCR domain) with Serine Protease domain.	SR	-	−3.82
AGAP009509	60S ribosomal protein L9	Small RNA pathway	2.08	-

Transcripts related to immunity significantly differentially expressed transcripts following IVM ingestion. Inclusion and family classifications based on data provided by the insect immunoDB database [108] and other publications. Descriptions in blue text were annotated based on BLASTp results (e-value ≤ 10⁻³) (Additional file 10)
AMP anti-microbial peptide, CLIP clip-domain serine protease, FibR fibrinogen-related, LYSP lysozyme, PGRP peptidoglycan recognition proteins, SC signaling-cascade related, SR scavenger receptor, SRP serine protease, SRPN serine protease inhibitor

ISSN: 1471-2164