Fig. 6

The PAG midnight blue module and cortex red module show enrichment in known protein-protein interactions. Protein-protein interactions were plotted using the DAPPLE tool. The proteins are coloured according to the significance of the degree of interactions tested with 5000 permuted networks. Genes with significantly higher degrees of direct protein interactions than expected (p-value ≤ 0.02) form a tightly clustered centre. a Most proteins within the midnight blue PAG module are significantly enriched with direct interactions, with the strongest connections amongst synaptic proteins such as the glutamate receptors; GRMs (mGluR) and GRINs (NMDA), highlighting their importance as hub genes. b Enrichment of direct interactions is overall much weaker in the cortex red module