Fig. 4

The interaction landscape spanning 500 kb around the promoter of Cd4 in mouse (mm9) double positive (CD4+ CD8+) thymocytes. The height of each curve corresponds to the number of PETs supporting that interaction. The resolution of the data is not high enough to detect interactions within the Cd4 gene region, however numerous interactions with both neighbouring 100 kb regions and distal regions on the same chromosome are observed (shown in light blue). The 100 kb region containing Cd4 also participates in at least one trans-chromosomal interaction (dark grey line). Tracks displaying Ensembl protein-coding genes and enhancers active in the mouse thymus [52] present in the region are also shown