Table 2 KEGG pathways affected by the direction of cross in F1 males (p < 0.05)
From: The direction of cross affects obesity after puberty in male but not female offspring
KEGG ID | Major category/Subcategory | Pathway Name | Proportion of genes in pathway | Identified genes 1 fold-change (matBFMI vs. patBFMI) | TFBS 2 | Corrected P-Value for pathway ORA |
|---|---|---|---|---|---|---|
Organismal Systems/ Environmental adaptation | Circadian rhythm | 10 % | Arntl (0.54) | - | 0.00087 | |
Per2 (1.32) | - | |||||
Per3 (1.71) | - | |||||
Cellular Processes/Transport and catabolism | Peroxisome | 5 % | Abcd1 (1.22) | - | 0.00094 | |
Abcd2 (1.52) | - | |||||
Acsl3 (1.22) | - | |||||
Crat (1.27) | - | |||||
Metabolism/Metabolism of cofactors and vitamins | Retinol metabolism | 5 % | Cyp2c38 (1.61) | Esrra, Esrrb | 0.00113 | |
Cyp2c39 (1.29) | Esrra, Esrrb | |||||
Cyp4a10 (1.35) | ERE, IR3 | |||||
Cyp4a14 (1.32) | - | |||||
Metabolism/Lipid metabolism | Arachidonic acid metabolism | 4 % | Cyp2c38 (1.61) | Esrra, Esrrb | 0.00099 | |
Cyp2c39 (1.29) | Esrra, Esrrb | |||||
Cyp4a10 (1.35) | ERE, IR3 | |||||
Cyp4a14 (1.32) | - | |||||
Metabolism/Lipid metabolism | Fatty acid degradation | 6 % | Acsl3 (1.22) | - | 0.00198 | |
Cyp4a10 (1.35) | ERE, IR3 | |||||
Cyp4a14 (1.32) | - | |||||
Metabolism/Lipid metabolism | Fatty acid biosynthesis | 14 % | Acsl3 (1.22) | - | 0.00282 | |
Fasn (1.22) | ERE | |||||
Organismal Systems/ Endocrine system | PPAR signaling pathway | 4 % | Acsl3 (1.22) | - | 0.00617 | |
Cyp4a10 (1.35) | ERE, IR3 | |||||
Cyp4a14 (1.32) | - | |||||
Metabolism/ Lipid metabolism | Fatty acid elongation | 8 % | Acot4 (1.82) | - | 0.00627 | |
Elovl6 (1.32) | - | |||||
Metabolism/Lipid metabolism | Steroid hormone biosynthesis | 4 % | Cyp2c38 (1.61) | Esrra, Esrrb | 0.00636 | |
Cyp2c39 (1.29) | Esrra, Esrrb | |||||
Cyp7b1 (0.83) | - | |||||
Metabolism/ Lipid metabolism | Biosynthesis of unsaturated fatty acids | 8 % | Acot4 (1.82) | - | 0.00635 | |
Elovl6 (1.32) | - | |||||
Organismal Systems/Circulatory system | Vascular smooth muscle contraction | 2 % | Avpr1a (0.77) | - | 0.01549 | |
Cyp4a10 (1.35) | ERE, IR3 | |||||
Cyp4a14 (1.32) | - | |||||
Environmental information processing/Membrane transport | ABC transporters | 4 % | Abcd1 (1.22) | - | 0.01649 | |
Abcd2 (1.52) | - | |||||
Metabolism/ Lipid metabolism | Linoleic acid metabolism | 4 % | Cyp2c38 (1.61) | Esrra, Esrrb | 0.01884 | |
Cyp2c39 (1.29) | Esrra, Esrrb | |||||
Organismal systems/Immune system | Hematopoietic cell lineage | 2 % | Dntt (1.24) | - | 0.04814 | |
Il1r1 (0.74) | - |