Fig. 1

P. aeruginosa sequential isolates from patient RP. Two clone types (OC2E and OC4A) of P. aeruginosa strains were isolated from patient RP who is heterozygous for F508del and R1162X mutations in the CFTR gene. OC2E was isolated at the onset of chronic colonization for the first eleven years. Thereafter OC4A became the dominant clone. Strain RP1 belongs to the clone type OC2E and was the first P .aeruginosa strains isolated. Strains RP45 and RP7 belong to the clone type OC4A and were isolated after 10 and 16.9 years respectively after the onset of chronic colonization of the patient’s airways with P. aeruginosa (Additional file 1 and Cramer et al. [12]). Lung function parameters at the time of P. aeruginosa isolation are indicated