Fig. 1

An example of a known long-range enhancer–promoter interaction in the human MYC locus. A 2-Mb genomic interval around the human MYC locus (genome assembly hg19) is shown in the UCSC Genome Browser. There are three tracks (from the top): (i) contact profile at 10-kb resolution obtained from Hi-C data; (ii) profile for H3K4me1; and (iii) profile for DNase I hypersensitivity sites, for each of the six cell types (GM12878, K562, IMR90, HUVEC, HMEC, and NHEK). Different colors are used for each of the six cell types. The anchor, which contains the transcription start site of MYC, is indicated by dark-colored highlights in the contact profiles. The colorectal cancer associated SNP, rs6983267, and gene annotations are shown at the bottom. The position of the SNP and the corresponding peaks in the profiles are indicated by a rounded rectangle