Fig. 4

BRCA and PARP synthetic lethality is identified by the BiSEp toolkit. a The expression distribution of BRCA1 and PARP3 across 811 CCLE cell lines. This pair was detected by BiGEE as the two genes are never expressed at low levels together (below the bimodal midpoint of expression). b The expression distribution of PARP3 (orange) coloured by BRCA2 loss (black). This pair was detected by the BEEM analysis. BRCA2 mutation is never seen where PARP3 expression is low