Fig. 1

Diagram of the L1Tc element including the Pr77 sequence. a Diagram of the L1Tc retrotransposon from T. cruzi. The coding sequences for AP endonuclease (AP), reverse transcriptase (RT), RNaseH (RH), the nucleic acid chaperone (NAC) proteins, and a 2A-self cleaving sequence, are shown in boxes. The Pr77 internal promoter is represented by a black flag, and the L1TcRz ribozyme by an empty arrow-head. The sequence of the Pr77 promoter is shown and the DPE motif labelled in bold face. b Alignment of the nucleotide sequences of the 5′ region of the different types of insect retrotransposon and developmentally regulated genes. The transcription start sites are underlined when known. Nucleotides are numbered from the transcription start site position (+1). The DPE motif is indicated in bold. A diagram of the DPE motif consensus (CGTG) with the CGTT variant for the TRAS1 retroelement is shown below the alignment