Fig. 3

Isoform expression and gene structure of CTNND1. a Gene and isoform expression of CTNND1 in the TCGA BRCA dataset. The total gene expression of CTNND1 provides comparable level in luminal and basal tumors, whereas the abundance of two CTNND1 isoforms, uc001nlo.3 and uc001nlt.3, exhibit inversely correlated differential expression in luminal and basal tumors. b Isoform expression of CTNND1 in the TCGA PanCan12 data set. The expression pattern of uc001nlo.3 and uc001nlt.3 pairs is similarly observed in the PanCan12 Luminal BRCA and Basal BRCA tumors, as well LUAD and Squamous clusters. c CTNND1 gene structure. The two isoforms are transcribed from the same transcription start site and provide alternative splicing in exon 20 (red arrow)