Fig. 5
From: Seasonal immunoregulation in a naturally-occurring vertebrate
ARACNe network (Network 3) of all immune-associated genes (ImmPort comprehensive list of immune-related genes), specifying seasonally-biased core immune genes as hubs. a Nodes, shown in a modified force-directed network, represent gene module sizes associated with hubs and edges are Jaccard similarity coefficients for module composition (cut-off, 0.1). Node colours indicate modules significantly enriched in winter-biased genes, summer-biased genes or both (see key). Modules associated with hubs that were winter-summer interface nodes in Network 1 tended to be large, to share a high degree of similarity in composition, and to contain significant enrichments of both winter- and summer-biased genes. b Form of simple structural equation model (path analysis) used in assessing the influence of winter-summer interface (key) genes from Network 1; W, main axis of covariation in winter-biased core immune genes (represented by the first principal component of a principal components analysis); S, main axis of covariation in summer-biased core immune genes; grey circle, expression of individual winter-summer interfacing gene