A loss of function variant in CASP7 protects against Alzheimer’s disease in homozygous APOE ε4 allele carriers

BMC Genomics

Table 1 The analyzed datasets in this study

Dataset	Samples	Cases	Controls	APOE ε4 Homozygotes….
Dataset	Samples	Cases	Controls	All	Cases	Controls
Mt. Sinai All	13,710	238	5325	93	8	85
White				25	1	24
African American				37	3	34
Hispanic/Latino				28	4	24
GHS	7645	287	7358	132	6	126
GBAD	1588	806	782	103	92	11
ADNI	2826	370	569	91	55	28
ADGC	6065	3666	1604	456	419	25
ADSP	10,939	6311	4628	145	96	1
TOTAL	42,773	12,248	20,067	1020	572 (EUR > 60)	190 (EUR > 60)

Some of these numbers may not sum due to various filtering steps. The final case/control totals for the APOE ε4 homozygotes include only those analyzed in the meta-analysis, and thus do not include the Mt. Sinai or ADSP datasets

ISSN: 1471-2164