Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders

Kaushik, Gaurav; Xia, Yu; Yang, Luobin; Thomas, Michael A.

doi:10.1186/s12864-016-2784-1

Table 1 Ranked gene list from the mixture treatment (50 most up- and down-regulated)

From: Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders

Up-regulated genes					Down-regulated genes
Rank	Genes	Fold change	P-value	Fold change in fish brains	Rank	Genes	Fold change	P-value	Fold change in fish brains
1	FAM129A	3.25	0.000		17350	ANGPTL4	−3.36	0.000
2	CACNA2D3	1.99	0.000	0.90	17349	THBS1	−2.19	0.000	0.34
3	NUPR1	1.97	0.002	−0.10	17348	STARD13	−2.17	0.000	−0.46
4	GRM8	1.90	0.000		17347	DRP2	−2.15	0.000
5	PTCHD1	1.89	0.000		17346	TNNT2	−2.11	0.000	−0.23
6	TMEM132C	1.76	0.000		17345	AQP10	−2.10	0.000
7	DDIT3	1.55	0.000	0.73	17344	STRA6	−1.97	0.000	−0.10
8	XKR4	1.53	0.010		17343	PAPPA2	−1.92	0.000
9	CHRNA10	1.33	0.002		17342	NEDD9	−1.88	0.000	−1.21
10	LPHN3	1.24	0.004		17341	GGTA1	−1.85	0.001
11	SERPINF2	1.23	0.008	0.15	17340	SH3TC1	−1.83	0.000
12	NKX3-1	1.22	0.008		17339	ADAMTSL2	−1.80	0.000	−0.25
13	HRK	1.22	0.051		17338	RGS13	−1.78	0.000
14	SCARNA20	1.22	0.009		17337	ANO1	−1.77	0.000
15	PABPC3	1.21	0.006		17336	LOC283731	−1.75	0.000
16	KIT	1.18	0.001	0.15	17335	CMKLR1	−1.73	0.000	0.86
17	KIAA1045	1.18	0.002	−0.12	17334	VIP	−1.71	0.000
18	DLL1	1.15	0.013	0.05	17333	HTR2B	−1.69	0.000
19	C9orf150	1.12	0.000		17332	RAG2	−1.67	0.004	0.20
20	SNORA14A	1.11	0.164		17331	ACVRL1	−1.67	0.000
21	B3GALT1	1.09	0.134		17330	VCAN	−1.66	0.000
22	RIMBP3C	1.09	0.096		17329	C6	−1.65	0.006	−1.11
23	NOS1AP	1.06	0.172	0.37	17328	ENO3	−1.64	0.000	−0.00
24	GLYATL2	1.06	0.021		17327	TM4SF1	−1.63	0.008	0.22
25	STAC2	1.04	0.259		17326	PCTK3	−1.62	0.004
26	CRYBB2	1.04	0.020	0.01	17325	FAM65C	−1.60	0.000
27	SLC16A10	1.01	0.167	−0.31	17324	FLJ36208	−1.60	0.000
28	CDH7	1.01	0.031	−0.00	17323	LOC400950	−1.58	0.000
29	MYB	1.01	0.030	−0.17	17322	RARRES3	−1.58	0.000
30	LCA5L	1.00	0.176		17321	SLCO4C1	−1.53	0.000
31	ID4	0.99	0.033	−0.17	17320	PRAP1	−1.52	0.022
32	MALAT1	0.99	0.004		17319	SLC18A1	−1.51	0.000
33	SNAR-A3	0.99	0.230		17318	TFPI2	−1.51	0.000
34	EDN1	0.98	0.033		17317	FBP1	−1.50	0.000	0.43
35	VSTM2A	0.97	0.000		17316	FGL1	−1.49	0.001
36	HERV-FRD	0.97	0.036		17315	COL9A3	−1.48	0.001
37	CNTD1	0.97	0.037	−1.03	17314	LRRTM1	−1.48	0.015	0.25
38	ELL2	0.96	0.000	−0.30	17313	BTK	−1.48	0.000	−0.30
39	SLC13A3	0.96	0.027	0.02	17312	SLC24A2	−1.46	0.000	0.11
40	DENND1B	0.96	0.114	0.06	17311	IRF6	−1.45	0.000	0.17
41	CYP2C18	0.95	0.041		17310	LOC392232	−1.45	0.012
42	AMN	0.95	0.041	−0.33	17309	RD3	−1.45	0.000
43	NCRNA00087	0.95	0.301		17308	DDC	−1.43	0.000
44	FUT9	0.94	0.042	−0.19	17307	PRLHR	−1.43	0.008
45	SCGB1D2	0.92	0.047		17306	NOTUM	−1.42	0.052	−0.31
46	TRIB3	0.92	0.000	0.67	17305	TMIGD2	−1.41	0.008
47	MYBL1	0.91	0.019		17304	RTL1	−1.40	0.048	−0.40
48	ZNF726	0.91	0.260		17303	P2RX6	−1.40	0.000
49	DLEU1	0.90	0.173		17302	DKK1	−1.39	0.000
50	SLC7A11	0.90	0.309	−0.41	17301	TRIM9	−1.38	0.000

Table representing the list of 50 most up- and down-regulated genes in human neuronal cells treated with the mixture (FLX, VNX, CBZ). Genes were ranked based on their expression in fold-change in human cells. P-value represents the significance level of the expression change in the mixture treatment than control. Corresponding fold change of genes in fish brains is also reported in this table, where blank cells represents genes that are not found in the fish microarray chip

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ISSN: 1471-2164

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