Fig. 6

A CHRNB1 frameshift mutation is associated with arthrogryposis multiplex congenita (AMC). A single G deletion, which was homozygous in all analysed cases, is marked by a red arrow. a IGV screenshot of the sequence alignments of three affected calves are displayed. Read pairs mapping to chromosome 19 are displayed in grey. Note the dashed black vertical line indicating the genome position of the G deletion. b Electropherograms of an AMC affected calf (case), a heterozygous carrier animal and normal control are shown. c The schematic representation of the bovine CHRNB1 gene indicates that the 1 bp deletion is located in the first exon