Fig. 5

Modeling and stability prediction features in G23D. a A G23D model displaying the mutant structure instead, or together with, the wild type. The modeling is done using Sccomp, a side chain prediction program. b Contact surface areas between atoms and solvent accessible surfaces are analytically calculated using Voronoi tessellation. This procedure allocates the surface area of each atom to its neighbors (colored arcs) and the solvent (dashed arc). c A residue-level summary table lists all contacts and minimal distance to contacting residues for both wild type and mutant structures. Database residues are colored according to the general coloring of G23D. d By pressing on a residue in the left column of the residue-level table, the user can explore all atomic level interactions between the input variant and the chosen residue