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Table 2 Amino acid residue changes resulting from non-synonymous nucleotide polymorphisms, including insertions/deletions, compared to the reference isolate (F2 strain) of FHV-1

From: Low genetic diversity among historical and contemporary clinical isolates of felid herpesvirus 1

Gene

AA changea

Variant isolates b

Unique long region

UL1

F4L

135/68

UL3.5

V15I

2004/2005

UL5

T7I

124/68, 3235/06, 3236/06, 3238/06

UL13

S25P

85/68, 117/68, 124/68, 135/68, 221/71, 356/75, 385/75, 448/77, 571/79, 729/83,3235/06, 3236/06, 3238/06

UL16

F344V

2004/2005

UL17

R519Q

2004/2005

UL21

A48D

3234/05

UL25

T60A

2004/2005

UL27

P872L

3235/06, 3236/06, 3238/06

UL28

Q427P

All

UL29

S1089P

Field

UL30

M943I

3228/05, 3230/05

I153T

729/83

UL35

R3S

NC_013590

UL36

G2503E

3230/05

V1310M

124/68

T2565M

221/71

N2936-

135/68

V2937-

135/68

Q2980K

117/68

P2838S

85/68, 117/68, 124/68, 135/68, 221/71, 356/75, 385/75, 448/77, 571/79, 729/83, 3235/06, 3236/06, 3238/06

UL37

L866F

2004/2005

UL38

I277M

Field

UL40

V66I

Field

UL44

E133K

All

UL45

R102H

729/83

UL49

T104I

3236/06

UL52

Y484C

Field

S579I

3225/05

UL54

I206V

2004/2005

S60P

135/68

UL55

I78M

Field

V1

D59G

124/68

ICP0

S412F

356/75, 571/79

Unique short region

US7

M165T

Field

P186S

124/68, 3235/06, 3236/06, 3238/06

Repeat region

ICP4

T156N

124/68, 3235/06, 3236/06, 3238/06

A419V

85/68, 117/68, 124/68, 135/68, 221/71, 3235/06, 3236/06, 3238/06

H875Q

385/75

V983A

356/75, 571/79, 3224/04, 3225/05, 3226/05, 3227/05, 3228/05, 3229/05, 3230/05, 3231/05, 3232/05, 3233/05, 3234/05

E1034K

3235/06, 3236/06, 3238/06

E1054G

2004/2005

US1

L261-

85/68

  1. a AA amino acid change
  2. bRelative to the vaccine isolates (F2 FHV-1 strains from the Feligen/Companion vaccines). All = Variant found in all non-vaccine isolates, Field = Variant found only in all Australian isolates sequenced in this study, 2004/2005 = Variant unique to 2004/2005 field isolates