Fig. 3

Protein-protein interactions network among genes transiently expressed at passage 14. The list of 101up-regulated (a) and 80 downregulated (b) unique gene identities were analysed with STRINGv10 (http://string-db.org/) by limiting the prediction methods to co-expression, experiments, databases and textmining. The required confidence score was set to highest (0.900) in (a) and high (0.700) in (b) and the unconnected nodes (proteins) were hidden. In (a), enrichment was set to the term mitotic nuclear division (GO:0007067; p = 2.7e-04) with proteins colored in red. Asterisks and red ovals depict centralspindlin (*), chromosome passenger (**) and MCM (***) complexes. Blue ovals enclose indicated additional GO terms; ECM stands for extracellular matrix. In (b), enrichment was set to response to ER stress (GO:0034976; p = 1.4e-03) and asterisks indicate tumor suppressor genes. The type of interaction is defined by color lines at bottom right. Detailed GO terms are described in Table 1. In (A), the protein D2Ertd750e corresponds to the updated Knstrn gene