Fig. 8

Correlation between alterations in DNA methylation and gene expression. a and c Heatmaps shows sequence density of significantly-regulated 5hmC regions sorted by RNA-Seq gene expression levels for the 0.1 (a) and 0.2 (c) Gy dose. Note the cluster of upregulated DIP-Seq data in intragenic regions at the top of the plot. The black bar denotes the position of scaled RefSeq intragenic regions. b and d Gene ontology analyses of the top 500 most up-regulated DIP-Seq regions (by normalized intragenic sequence difference) in the corresponding heatmaps of the 0.1 (b) and 0.2 (d) Gy doses. e Diagram depicts a subset of genes present in the synapse gene ontology category in D. Note the orthologs and preo/post-synaptic components. f and g UCSC genome browser track depicts DIP-Seq sequence density at two differentially hydroxymethylated gene selected from panels b and d Hatch marks may represent multiple sequences