Fig. 7

Co-expression networks of highly significant (a) down-regulated and (b) up-regulated genes in AAE6 vs. EPE6. a Four discrete clusters of down-regulated and co-expressed genes were observed. Only co-expressed genes with a Pearson correlation coefficient greater than 0.95 are shown. Clusters are labelled by number and functionally annotated with their significantly enriched biological process. Nodes = gene, denoted by gene symbol; node colour = white to red with down-regulation (fold change) in AAE6 from EPE6; edge thickness = increases with Pearson correlation coefficient. b Five discrete clusters of up-regulated and co-expressed genes were observed. Only clusters co-expressed genes with a Pearson correlation coefficient greater than 0.996 and are shown, to narrow down the number of genes displayed. Clusters are labelled by number and functionally annotated with their significantly enriched biological process. Nodes = gene, denoted by gene symbol; node colour = white to green with up-regulation (fold change) in AAE6 over EPE6; edge thickness = increases with Pearson correlation coefficient. See Additional file 4 for discussion