Fig. 7From: Chromosome3D: reconstructing three-dimensional chromosomal structures from Hi-C interaction frequency data using distance geometry simulated annealingQuality of top structures at different values of α for simulated data with 5, 10 and 20 % noise. Spearman’s average rank correlation coefficient (against the input IF) is used to evaluate the quality of structures. The closer to − 1 the correlations are, the better structures. The structures are too compact for small α and too loose for large αBack to article page