Fig. 2

Ctr9 knockdown decreases genome-wide ERα occupancy. a A matrix describing the approach used to identify differential ERα binding sites. b Aggregate plot showing the genomic binding profiles of ERα on ERα binding regions under the indicated four treatment conditions. c Heatmaps showing the ERα occupancy on ± 5 kb of ERα binding peak centers in the indicated four treatment conditions. The black arrow denotes the center of ERα binding peaks. d Venn diagram showing the overlaps between E2-induced ERα binding sites, E2-induced ERα binding sites in the context of Ctr9 knockdown (KD), and Ctr9 KD decreased ERα binding sites in the presence of E2. e De novo motif analyses of the three sets of ERα binding sites noted in (d)