Table 1 Overview of proposed host-symbiont interaction proteins

peptidoglycan recognition proteins (PGRPs)

6 (16)

1

C-type lectins

33 (119)

5

R-type lectins

6 (18)

4

SUEL/rhamnose-binding lectins

7 (22)

1

galectins

3 (3)

1

fucolectin

1 (23)

0

fibrinogen-related proteins (FREPs)

27 (161)

1

toll-like/variable lymphocyte receptor-like (TLR/VLR)

13 (52)

1

scavenger receptor cysteine-rich (SRCR) domain proteins

25 (164)

1

beta-1,3-glucan binding protein

1 (1)

1

novel immunoglobulin I-set proteins

16 (17)

1

novel immunoglobulin V-set proteins

9 (22)

1

lumbricin

1 (1)

1

invertebrate-type lysozyme

1 (1)

0

bactericidal permeability increasing protein BPI

1 (3)

1

insect defensin/reeler-like proteins

4 (8)

1

cysteine-rich secretory proteins (CRSPs)

6 (28)

2

membrane attack complex/perforin

2 (23)

0

ROS modulator 1

2 (3)

1

alpha-2-macroglobulin

10 (24)

1

kazal-type serpin

2 (8)

0

kunitz-type serpin

1 (2)

0

leukocyte elastase inhibitors

5 (25)

1

phosphatidylethanolamine-binding protein PEBP

3 (5)

1

Toll/interleukin-1 receptor (TIR) domain proteins

5 (9)

0

NF-kappa-B inhibitor Cactus

2 (6)

0

dorsal protein

2 (3)

1

evolutionarily conserved signaling intermediate in Toll (ECSIT)

1 (1)

0

Pelle protein

1 (1)

0

Relish protein

1 (6)

0

mitogen-activated protein kinase kinase kinase 7 (TAK1)

1 (1)

0

I-kappa-B-kinase alpha (IKK α)

1 (1)

0

I-kappa-B-kinase beta (IKK β)

1 (5)

0

interleukin-1 receptor-associated kinase 1 (IRAK1)

1 (2)

0

mitogen-activated protein kinase kinase kinase 4 (MEKK4)

1 (1)

0

sterile alpha and TIR motif-containing protein (SARM)

1 (3)

0

Toll-interacting protein Tollip

1 (2)

1

(LPS-induced) tumor necrosis factor (TNF)

3 (7)

0

Tumor necrosis factor (TNF)

4 (6)

0

tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

1 (3)

0

tumor necrosis factor receptor associated proteins (TRAF)

9 (16)

0

IFN regulatory factor

8 (10)

0

IFN regulatory factor-binding protein

1 (1)

0

IFN-induced GTPase

7 (23)

1

macrophage migration inhibitory factor (MIF)

3 (24)

1

ILN enhancer binding factor 2

2 (4)

1

ILN-16

1 (1)

0

carboxypeptidases

11 (22)

0

cathepsins total

15 (28)

4

cathepsin B

3 (12)

1

cathepsin C

2 (4)

0

cathepsin F

3 (3)

1

cathepsin L

5 (6)

2

cathepsin O

1 (2)

0

cathepsin Z

1 (1)

0

chymotrypsins

3 (17)

1

pancreatic elastase

1 (1)

1

alpha amylase

2 (3)

1

lysosomal alpha glucosidase

1 (3)

1

acid trehalase

2 (4)

1

sucrase-isomaltase

1 (1)

0

lysosomal acid lipase

1 (1)

0

hemerythrin

2 (2)

2

giant extracellular hemoglobin, globin chains

12 (16)

8

giant extracellular hemoglobin, linker chains

6 (18)

5

sum

316 (1032)

60