Table 3 Relation between differentially methylated genes and downstream expressed genes of blastocysts originating from oocytes exposed to high NEFA concentrations
Associated pathways | Differentially methylated genes | Downstream differentially expressed genes |
|---|---|---|
Apoptosis | TP53 | SIRT1, MAD2L1, FAM3C, CDC7, CD47, HERC5, HSPD1,SCP2, UBL3, ID3 |
Embryo implantation | LIF | GPCPD1, CYP11A1 |
Gene transcription | CTBP1 | SIRT 1 |
IGF1R | PDCD10, SCP2, KRT19, CYP11A1 | |
Immune response | TCR | HERC5, HSPD1, GBP4, ID3 |
RXRB | CCL17 | |
Metabolism | G6PC | CYP11A1 |
LEP | SC4MOL, SCP2, TIMP1 | |
PEPCK | CYP11A1 |