Table 5 Relation between differentially methylated genes and downstream expressed genes of blastocysts originating from embryos exposed to high NEFA concentrations
Associated pathways | Differentially methylated genes | Downstream differentially expressed genes |
|---|---|---|
Apoptosis | TP53 | SERPINE1, DCTN2, CNN3, BHLHB2, MTDH, ASNS, GLB1, CNN1, HMGCS1, CCND2, LBR, ANKH, NANOG, SEC61B, HSPG2, COX7A2, GZMB, IGFBP7 |
Autophagy | ATG16L1 | UPK1A |
Cell cycle | TERF2 | GLB1 |
Cell differentiation | FGFR2 | CCND2, NANOG, NR5A2 |
Cell interaction | Alpha catenin | RHOC, IGFBP7, TWIST2 |
Cell signaling | ERK1/2 | SERPINE1, CCND2, LDLR, NANOG, RHOC |
ITGAV | SERPINE1, LDLR | |
Cell survival | FGF10 | SCD, LDLR, LFNG |
Cellular development | THPO | CCND2, GP1BA |
Hormonal regulation | estrogen receptor | SERPINE1, CCND2, LDLR, MUC1 |
FSH | SERPINE1, CCND2, LDLR, AQP3, ARL4C, GZMB, CARD10, DUSP14, GATA4 | |
FSHR | GATA4, GZMB∆ | |
Immune response | CD28 | TOM1L1, CCND2, TXNRD1, PA2G4, AQP3, SEC61B, RHOC, GZMB, DUSP14 |
Cg | BHLHB2, CCND2, LDLR, S100A10, NR5A2, GATA4 | |
TCR | LBR, PA2G4, GZMB, ARPP21, LMNB1 | |
Ion transport | WNK1 | SERPINE1 |
Gene transcription | Creb | MIF, HSPB8, LDLR, ELL |
PRDM16 | SERPINE1 | |
SMARCA4 | SERPINE1, MUC1, ASNS, FLNB, TXNRD1, ARL4C |