Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles

Schlegel, Markus; Münsterkötter, Martin; Güldener, Ulrich; Bruggmann, Rémy; Duò, Angelo; Hainaut, Matthieu; Henrissat, Bernard; Sieber, Christian M. K.; Hoffmeister, Dirk; Grünig, Christoph R.

doi:10.1186/s12864-016-3369-8

BMC Genomics

Table 5 Key secondary metabolite genes found in the genome of P. subalpina

From: Globally distributed root endophyte Phialocephala subalpina links pathogenic and saprophytic lifestyles

Class	Type	Gene code	SM cluster^a	Length (aa)	Domain structure^b	Remarks
NRPS-like	L-alpha-aminoadipate reductase	PAC_02750		1167	A-T-R	Lys2, L-lysine biosynthesis
NRPS-like	adenylating reductase	PAC_02944	8	1049	A-T-R
NRPS-like	adenylating reductase	PAC_01324	3	1047	A-T-R
NRPS-like	adenylating reductase	PAC_02391	6	1023	A-T-R
NRPS-like	adenylating reductase	PAC_03877	10	1117	A-T-R
NRPS-like	adenylating reductase	PAC_04959	12	1038	A-T-R
NRPS-like	adenylating reductase	PAC_05733		1008	A-T-R
NRPS-like	adenylating reductase	PAC_07003		1054	A-T-R
NRPS-like	adenylating reductase	PAC_12811		1054	A-T-R
NRPS-like	adenylating reductase	PAC_17490		1065	A-T-R
NRPS-like	adenylating reductase	PAC_19780		1050	A-T-R
NRPS-like	adenylating reductase	PAC_02202	5	1227	A-T-R-Kinase
NRPS-like	adenylating reductase	PAC_08842		1345	A-T-R-KR
NRPS-like	furanone synthetase	PAC_08910	17	1013	A-T-TE
NRPS-like	quinone synthetase	PAC_14584		979	A-T-TE
NRPS-like	unknown	PAC_19640		1394	A-T-DUF
NRPS-like	unknown	PAC_12359		1655	A-T-DUF
NRPS		PAC_05248	13	4676	A-T-C-A-T-C-A-T-C-T-C-T-C	Siderophore biosynthesis (Ferrichrome-like)
NRPS		PAC_13158		4838	A-T-C-A-T-C-T-C-A-T-C-T-C-T-C	Siderophore biosynthesis (Ferrichrome-like)
NRPS		PAC_15746		1639	A-T-C-T-C
NRPS		PAC_20134		4692	C-A-T-C-A-T-C-A-T-C-A-T-C-T
NRPS		PAC_16560		565	A-T-C
NRPS		PAC_16746		1207	A-T-C
NRPS		PAC_19282		1220	A-T-C
PKS-NRPS		PAC_02326		3974	KS-AT-DH-MT-KR-T-C-A-T-R
PKS-NRPS		PAC_08246	16	3965	KS-AT-DH-MT-KR-T-C-A-T-R
Type I PKS	non-reducing PKS	PAC_01338	4	2542	SAT-KS-AT-PT-T-MT-TE	Citrinin biosynthesis-like
Type I PKS	non-reducing PKS	PAC_02435	7	2498	SAT-KS-AT-PT-T-MT-TE	Citrinin biosynthesis-like
Type I PKS	non-reducing PKS	PAC_03302		2223	KS-AT-DH-T-TE
Type I PKS	non-reducing PKS	PAC_03589	9	1670	KS-AT-PT-T-TE
Type I PKS	non-reducing PKS	PAC_07895	15	2171	SAT-KS-AT-PT-T-T-TE	Likely melanin biosynthesis
Type I PKS	non-reducing PKS	PAC_08751		2099	SAT-KS-AT-PT-T-T-TE
Type I PKS	non-reducing PKS	PAC_10081		2125	SAT-KS-AT-PT-T-T-TE
Type I PKS	non-reducing PKS	PAC_11435		2169	SAT-KS-AT-PT-T-T-TE	Likely melanin biosynthesis
Type I PKS	reducing PKS	PAC_00199	1	2694	KS-AT-DH-MT-ER-KR-T	Alternapyrone biosynthesis-like
Type I PKS	reducing PKS	PAC_00310	2	2283	KS-AT-DH-ER-KR-T
Type I PKS	reducing PKS	PAC_01646		1687	AT-DH-MT-ER-KR-T
Type I PKS	reducing PKS	PAC_04883	11	2239	KS-AT-DH-ER-KR-T
Type I PKS	reducing PKS	PAC_06141		2258	KS-AT-DH-ER-KR-T
Type I PKS	reducing PKS	PAC_10762		3173	KS-AT-DH-MT-ER-KR-T-Acyltransferase
Type I PKS	reducing PKS	PAC_11350		3203	KS-AT-DH-MT-ER-KR-T-Acyltransferase
Type I PKS	reducing PKS	PAC_14253		2590	KS-AT-DH-MT-ER-KR-T
Type I PKS	reducing PKS	PAC_14645		2274	KS-AT-DH-ER-KR-T
Type I PKS	reducing PKS	PAC_16276		3140	KS-AT-DH-MT-ER-KR-T-Acyltransferase
Type I PKS	reducing PKS	PAC_17799		2411	KS-AT-DH-ER-KR-T	Lovastatin-diketide synthase-like
Type I PKS	reducing PKS	PAC_19082		2581	KS-AT-DH-MT-ER-KR-T
Type I PKS	reducing PKS	PAC_19990		2970	KS-AT-DH-MT-KR-T-C	Lovastatin-nonaketide synthase-like
Type I PKS	reducing PKS	PAC_10712		1430	KS-AT-TH-KR-T	6-Methylsalicylate synthase-like PKS
Type III PKS		PAC_02116		479	IPR012328/IPR001099
DMATS		PAC_15749		538	IPR017795
Terpene		PAC_05884		483
Terpene		PAC_13844		593	IPR017825/IPR017825/IPR002060	Squalene synthase-like
Terpene		PAC_15298		557
Terpene		PAC_01018		338	IPR008949
Terpene		PAC_04028		331	IPR008949
Terpene		PAC_11164		466	IPR008949
Terpene		PAC_12198		392	IPR008949
Terpene		PAC_16221		336	IPR008949

^a for details on the putative SM gene clusters see Additional file 3
^b Abbreviations for domains: A adenylation, AT acyltransferase, C condensation, DH dehydratase, DUF terminal NRPS domain of unknown function, ER enoyl reductase, KR ketoreductase, KS ketosynthase, MT methyltransferase, PT product template, R reduction, SAT starter unit-ACP-transacylase, T thiolation (=acyl- or aryl- or peptidylcarrier protein), TE thioesterase, TH thiohydrolase

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ISSN: 1471-2164

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