Fig. 4

Our model accurately predicts the cellular composition of blood samples and outperforms existing approaches in Affymetrix Gene ST data. Predicted cell proportions are plotted against the cell proportions obtained from CBC/diffs ((a); CHFP cohort) or a cell-type specific DNA methylation cell-typing assay ((b); Epiontis asthma cohort). In (a), the sum of the predicted B, CD4+ T, CD8+ T and NK cell proportions is compared to the total lymphocyte proportions from the CBC/diffs. The predicted granulocyte and monocyte proportions are directly compared. In (b), the sum of the predicted CD4+ and CD8+ T cell proportions is compared to T cell proportion from the Epiontis assay. The predicted monocyte and B cell proportions are directly compared. For each cell type, Pearson’s product–moment correlation (Pearson’s r) and the root mean squared error (RMSE) are reported